{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:37:45Z","timestamp":1789000665192,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["802830"],"award-info":[{"award-number":["802830"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,5,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Currently, there is major interest in embedding light\u2010responsive (supra)molecular systems in phospholipid bilayer membranes, for example, to control transmembrane transport processes. Most of these systems are operated by harmful UV\u2010light. Although in solution phase the isomerization of photoswitchable systems has been achieved using visible\u2010light\u2010absorbing photosensitizers, no cases are known yet of sensitized isomerization in a lipid bilayer environment. Herein, we show that the active isomer of a stiff\u2010stilbene based chloride transporter can be generated in situ by irradiation and energy transfer from a ruthenium tris(bipyridyl) complex. In the bilayer, this process is more efficient than in solution, as a benefit of the higher effective concentration of sensitizer and transporter upon confinement. Our work offers an approach to induce isomerization of membrane\u2010embedded systems by visible light, without the need of synthetic modification and loss of function or activity.<\/jats:p>","DOI":"10.1002\/anie.6015167","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T04:56:08Z","timestamp":1775451368000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Visible\u2010Light Sensitized Isomerization in the Lipid Bilayer Enables Activation of a Transmembrane Transporter"],"prefix":"10.1002","volume":"65","author":[{"given":"Julia","family":"Villalva","sequence":"first","affiliation":[{"name":"Leiden Institute of Chemistry Leiden University  CC Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Mondal","sequence":"additional","affiliation":[{"name":"Leiden Institute of Chemistry Leiden University  CC Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"Marulanda","sequence":"additional","affiliation":[{"name":"Leiden Institute of Chemistry Leiden University  CC Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper E.","family":"Bos","sequence":"additional","affiliation":[{"name":"Leiden Institute of Chemistry Leiden University  CC Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5810-3657","authenticated-orcid":false,"given":"Sylvestre","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Leiden Institute of Chemistry Leiden University  CC Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Pandit","sequence":"additional","affiliation":[{"name":"Leiden Institute of Chemistry Leiden University  CC Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9192-3393","authenticated-orcid":false,"given":"Sander J.","family":"Wezenberg","sequence":"additional","affiliation":[{"name":"Leiden Institute of Chemistry Leiden University  CC Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00039"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c08877"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202308842"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC07560A"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202000400"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC02745F"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c02249"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c05750"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202102838"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1OB01457A"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c10034"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c02612"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202204605"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.3c01018"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c10952"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c01884"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202420232"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.06.008"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.200500247"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201500628"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202205758"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/rpm.20230012"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4SC02538E"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/j100644a002"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/j100907a020"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00477a006"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja306986g"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC01717A"},{"key":"e_1_2_7_30_1","first-page":"4081","article-title":"Enabling Lower Energy Light Harvesting in Stilbene\u2010Based Photomechanical Polymers Via Triplet Sensitization","volume":"4","author":"Beery D.","year":"2022","journal-title":"ACS Applied Materials & 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isomerization was also noted in absence of sensitizer using 455\u00a0nm irradiation although conversion was much slower (Figure S9). This observation is tentatively ascribed to aggregation of (E)\u20101in the bilayer causing extension of the absorbance to longer wavelengths."},{"key":"e_1_2_7_56_1","unstructured":"Irradiation at 455\u00a0nm of POPC\u2010LUVs containing only [Ru(bpy)2(L1)]Cl2(2 mol%) did not result in any UV\u2010Vis spectral changes indicating that the ruthenium complex is photostable (Figure S10)."},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/j100385a020"},{"key":"e_1_2_7_58_1","unstructured":"Please note that in these comparatitive experiments the concentration of the components in DMSO is too low to produce observable excited\u2010state quenching."},{"key":"e_1_2_7_59_1","unstructured":"This difference in lifetime aligns with prior observations in vesicles composed from other phospholipids and has been ascribed to self\u2010quenching effects see reference [50]."},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2016.04.002"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2022.112633"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4MA00535J"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.6015167","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.6015167","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.6015167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:53:21Z","timestamp":1781693601000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.6015167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,5]]},"references-count":61,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,5,11]]}},"alternative-id":["10.1002\/anie.6015167"],"URL":"https:\/\/doi.org\/10.1002\/anie.6015167","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,5]]},"assertion":[{"value":"2026-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6015167"}}