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Herein, we report an efficient cobalt\u2010catalyzed desymmetric hydrogenation of structurally diverse cyclic 1,2\u2010 and 1,3\u2010diacid anhydrides, enabling access to pharmaceutically relevant chiral\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010 and\n                    <jats:italic>\u03b4<\/jats:italic>\n                    \u2010lactones with broad substrate scope and excellent enantioselectivity (up to 99% ee). The reaction is readily scalable, as demonstrated by gram\u2010scale synthesis of several representative products. Notably, this 3d\u2010metal catalytic platform represents a rare example that outperforms platinum\u2010group\u2010metal\u2010based counterparts in both generality and stereoselectivity. DFT studies identify a catalytically active d\n                    <jats:sup>7<\/jats:sup>\n                    Co(II) dihydride complex with an outer\u2010sphere hydride transfer mechanism, wherein a relatively flexible chiral pocket underlies the broad substrate compatibility of this catalytic system.\n                  <\/jats:p>","DOI":"10.1002\/anie.6111891","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:46:36Z","timestamp":1790739996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cobalt\u2010Catalyzed Desymmetrizing Hydrogenation of Cyclic Anhydrides"],"prefix":"10.1002","author":[{"given":"Lei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Chemistry and Shenzhen Grubbs Institute Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis Southern University of Science and Technology  Shenzhen 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