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Nevertheless, general and facile synthetic approaches toward multisubstituted glutarimides remain scarce, particularly for analogues with \u03b1, \u03b1\u2010disubstituted structures and substitutions at diverse sites of the imide core. In this work, we developed a radical alkylation\/cyclization cascade of \u03b1\u2010tertiary haloamides and acrylates using earth\u2010abundant titanium as the catalyst. This transformation provides a practical route to glutarimides featuring quaternary carbon centers and multi\u2010functionalized imide skeletons. Both\n                    <jats:italic>N<\/jats:italic>\n                    \u2010unsubstituted glutarimides and derivatives with tunable\n                    <jats:italic>N<\/jats:italic>\n                    \u2010substituents can be readily accessed, including analogues derived from bioactive and pharmaceutical scaffolds. Furthermore, the antiproliferative potency of these newly synthesized glutarimides was assessed using HeLa and glioblastoma U87 cell lines.\n                  <\/jats:p>","DOI":"10.1002\/anie.6119479","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:55:02Z","timestamp":1787979302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Titanium\u2010Catalyzed Synthesis of Multisubstituted Glutarimides Bearing Quaternary Carbon Centers\u2010Scope, Mechanism, and Bioactivity Studies"],"prefix":"10.1002","volume":"65","author":[{"given":"Wendi","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization Lanzhou Institute of Chemical Physics (LICP) Chinese Academy of Sciences  Lanzhou China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximei","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization Lanzhou Institute of Chemical Physics (LICP) Chinese Academy of Sciences  Lanzhou China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhui","family":"Tong","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Lanzhou University  Lanzhou Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4564-7743","authenticated-orcid":false,"given":"Min","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Materials Chemistry and Chemical Engineering Hangzhou Normal University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2982-2932","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Lanzhou University  Lanzhou Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0583-4832","authenticated-orcid":false,"given":"Lipeng","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization Lanzhou Institute of Chemical Physics (LICP) Chinese Academy of Sciences  Lanzhou China"},{"name":"Department of Chemistry School of Science Tianjin University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1054\/mehy.1999.0879"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960\u2010894X(96)00220\u2010X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.1996.tb16041.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab1433"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.4c00445"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202108848"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100042\u20101751450"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo962202c"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2008.05.030"},{"key":"e_1_2_8_11_1","first-page":"577","article-title":"\u00dcber Einwirkung von Ketonen auf Cyanessigs\u00e4ure\u00e4ther in alkoholischem Ammoniak; 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