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A chiral bicyclo[3.2.1]octane unit biases the reactive polyene conformation and controls stereochemical outcome remotely during cascade cyclization. This substrate\u2010encoded process enables highly diastereoselective construction of the 6\/6\/6\/5\n                    <jats:italic>ent<\/jats:italic>\n                    \u2010kaurenoic acid framework under visible\u2010light conditions. A convergent nickel\u2010catalyzed reductive cross\u2010electrophile coupling rapidly assembles the cyclization precursor. Late\u2010stage oxidation\u2010state and stereochemical editing from a common intermediate provide access to seven structurally distinct diterpenoids, including the first total synthesis of noueinsiancin D.\n                  <\/jats:p>","DOI":"10.1002\/anie.6268409","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:41:12Z","timestamp":1786452072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Total Synthesis of\n                    <i>ent<\/i>\n                    \u2010Kaurenoic Acid Diterpenoids Enabled by Distal Conformational Control in Photoredox Radical Polyene Cyclization"],"prefix":"10.1002","volume":"65","author":[{"given":"Jinbo","family":"Duan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Product Chemistry College of Chemistry and Chemical Engineering Lanzhou University  Lanzhou P. R. 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Numbers 2501073 (for20) 2501074 (for25) and 2545102 (for29) contain the supplementary crystallographic data for this paper. 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