{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:43:17Z","timestamp":1791877397174,"version":"4.3.4"},"reference-count":69,"publisher":"Wiley","issue":"38","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22474019"],"award-info":[{"award-number":["22474019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,9,14]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Circular RNAs (circRNAs) are key endogenous regulators of tumorigenesis and progression, and their high interspecies diversity and strong sequence homology pose a great challenge for simultaneous, live\u2010cell differentiation of multiple circRNA variants. Herein, we construct an intelligent nanoclassifier (DB\u2010CHA@PAN) by assembling disulfide bond (DB)\u2010modified catalytic hairpin assembly (CHA) probes onto programmable cruciform framework\u2010based nanoparticles (PAN) for spatioselective visualization of dual circRNAs and synergistic photodynamic therapy. Upon entering cancer cells, GSH cleaves disulfide bonds to initiate multiple rounds of circRNAs\u2010fueled cyclic CHA cascades, inducing spatial separation of photosensitizer (PS)\/BHQ3 and Cy3\/BHQ2 pairs and consequently recovery of PS photodynamic activity and Cy3 fluorescence signal. Released PS can generate abundant singlet oxygen (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) upon light irradiation, inducing oxidative damage and apoptosis. This intelligent nanoclassifier enables attomolar\u2010level detection of circCDYL and circHIPK3 in vitro and simultaneous imaging of circCDYL and circHIPK3 in living cells. It can quantify circRNA levels at single\u2010cell sensitivity, discriminate circRNAs from mismatched variants with single\u2010base resolution, and even diagnose breast\/lung cancer across entire clinical spectrum with 100% accuracy. Moreover, it can real\u2010time track circRNAs dynamics in living cells and MCF\u20107 tumor\u2010bearing nude mice, and significantly enhance therapeutic efficacy via synergistic photodynamic activation, with promising applications in clinical diagnostics and therapeutics.\n                  <\/jats:p>","DOI":"10.1002\/anie.6302768","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:08:41Z","timestamp":1783678121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Construction of a Glutathione\u2010Gated Intelligent Nanoclassifier for Spatioselective Visualization of Dual CircRNAs and Synergistic Photodynamic Therapy"],"prefix":"10.1002","volume":"65","author":[{"given":"Qian","family":"Liu","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering State Key Laboratory of Digital Medical Engineering Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenliang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010juan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering State Key Laboratory of Digital Medical Engineering Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering State Key Laboratory of Digital Medical Engineering Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202505289"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad770"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c02083"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(93)90279\u2010Y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.12.021"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adj8769"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.03.027"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007060\u20105"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2017.1279788"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.02.021"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010022\u201001563\u20103"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11993"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.08.019"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11928"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c18880"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576\u2010023\u201000662\u20101"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010023\u201001766\u20102"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.03.027"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010020\u201001231\u20104"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.02.004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2024.118112"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201010246\u20105"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010025\u201002157\u20107"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596\u2010023\u201000815\u2010w"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010019\u20101040\u20100"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201005096\u20106"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010020\u201001246\u2010x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010022\u201001501\u20103"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2021.113508"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.121021"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2021.339210"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaf1123"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2021.113783"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.153"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00589"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00445E"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00316A"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202400492"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202401711"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202505223"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b10529"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010023\u201001348\u20109"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c06252"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4364"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4071"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c05353"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2025.117728"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2023.135048"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c01272"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1071"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr5004198"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202112236"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202117401"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn2941"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103836"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2025.117273"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41525\u2010017\u20100038\u2010z"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.3c01814"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2025.118016"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr300358b"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c16001"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5c00907"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c05066"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00237"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC01001C"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.171092"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c05116"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13171483"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.164594"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.6302768","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.6302768","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.6302768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:09:32Z","timestamp":1789376972000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.6302768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":69,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2026,9,14]]}},"alternative-id":["10.1002\/anie.6302768"],"URL":"https:\/\/doi.org\/10.1002\/anie.6302768","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]},"assertion":[{"value":"2026-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6302768"}}