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However, current studies of PSs for increasing ROS yield mainly focus on the ground\u2010state configuration, ignoring the influence of the excited\u2010state distorted configuration. In this work, we designed a distorted pentamethine chain structure in the excited state with a rotatable, large steric hindrance electron\u2010withdrawing group (ethylbenzothiazole) in the meso\u2010position (\n                    <jats:bold>Cy\u2010S\u2010Y<\/jats:bold>\n                    ). Due to a new strategy of structural distortion\u2010enhanced intersystem crossing (SDE\u2010ISC),\n                    <jats:bold>Cy\u2010S\u2010Y<\/jats:bold>\n                    exhibited a superior capacity for singlet oxygen (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) generation (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    quantum yield (\n                    <jats:italic>\u03a6<\/jats:italic>\n                    <jats:sub>\u0394<\/jats:sub>\n                    ) = 44.7%) with low light power (3\u00a0mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ) in H\n                    <jats:sub>2<\/jats:sub>\n                    O, outperforming the\n                    <jats:bold>Cy\u2010Br<\/jats:bold>\n                    modified with heavy atoms (8.4\u2010fold). Theoretical calculations confirmed that\n                    <jats:bold>Cy\u2010S\u2010Y<\/jats:bold>\n                    had a distorted pentamethine chain structure in the T\n                    <jats:sub>2<\/jats:sub>\n                    state, resulting in a small energy gap (\u0394\n                    <jats:italic>E<\/jats:italic>\n                    <jats:sub>S1\u2010T2<\/jats:sub>\n                    = \u20100.002\u00a0eV) and a large spin\u2010orbit coupling constant (SOC = 0.29 cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), thereby promoting efficient ISC. In addition,\n                    <jats:bold>Cy\u2010S\u2010Y<\/jats:bold>\n                    \u2010mediated photoimmunotherapy promoted damage\u2010associated molecular patterns (DAMPs) and released immune\u2010stimulating factors in vitro. As a result,\n                    <jats:bold>Cy\u2010S\u2010Y<\/jats:bold>\n                    not only inhibited tumor growth but also improved the immune microenvironment and significantly prolonged survival in a tumor\u2010bearing mouse model.\n                  <\/jats:p>","DOI":"10.1002\/anie.6505397","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:43:51Z","timestamp":1790653431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Excited\u2010State Structural Distortion of Pentamethine Chains Enhances Singlet Oxygen Generation as a Photoimmunotherapeutic Agent"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9821-7838","authenticated-orcid":false,"given":"Ran","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center For Smart Materials Oriented Chemical Engineering Dalian 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