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Conventional methods provide bulk chemical information, but lack spatial and metabolic context. Here, we use matrix\u2010assisted laser desorption\/ionization mass spectrometry imaging (MALDI MSI) with trapped ion mobility spectrometry (TIMS) to localize PS across whole\u2010body murine sections and individual organs, allowing differentiation of PS chain lengths and associated metabolic shifts. Oral PS exposure produced clear organ\u2010specific lipid remodeling. In the stomach, increases in phosphatidylcholine (PC(30:2)), phosphatidic acid (PA(36:1)), and sphingomyelin (SM(34:1; O\n                    <jats:sub>2<\/jats:sub>\n                    )) suggest epithelial stress and barrier disruption. In the liver, PC(32:1) decreased, and higher PC(30:2) and PA(36:2) indicate impaired lipid export alongside compensatory adjustments to maintain membrane stability, with potential effects on systemic lipid balance. In the heart, reductions in SM(32:1; O\n                    <jats:sub>2<\/jats:sub>\n                    ), ether\u2010linked phosphatidic acid (PA(O\u201034:1)), and hexosylceramide (HexCer(30:1; O\n                    <jats:sub>2<\/jats:sub>\n                    )) reflect disrupted sphingolipid and ether\u2010linked lipid species metabolism and altered lipid transport. Together, these findings reveal dynamic, tissue\u2010specific lipid responses to PS exposure. This study shows that MALDI TIMS MSI provides high\u2010resolution, label\u2010free mapping of PS and its metabolic footprint and can be extended to other low\u2010abundance synthetic compounds.\n                  <\/jats:p>","DOI":"10.1002\/anie.6528604","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:40:52Z","timestamp":1776084052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Spatial Detection of Microsphere Polystyrene Plastics and Molecular Remodeling within a Full\u2010Body Mouse with MALDI Trapped Ion Mobility Mass Spectrometry Imaging"],"prefix":"10.1002","volume":"65","author":[{"given":"Karina A.","family":"Vargas","sequence":"first","affiliation":[{"name":"Department of Chemistry Department of Chemistry and Chemical Biology University of California Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6078-3321","authenticated-orcid":false,"given":"Elizabeth K.","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Chemistry Department of Chemistry and Chemical Biology University of California Davis  Davis California 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