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The benzene\u2010rich framework is conformationally inflexible and thus inherently chiral, adopting a saddle\u2010shaped conformation. A variety of heteroaromatic\u2010 and naphthalene\u2010embedded tetraphenylene analogues were prepared enantioselectively by routine transformations of the \u03b1\u2010hydroxy ketone moiety. Density functional theory (DFT) calculations elucidate the reaction mechanism and provide insights into the origin of the stereoselectivity.<\/jats:p>","DOI":"10.1002\/anie.6712761","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:07:21Z","timestamp":1777115241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Enantioselective Synthesis of Inherently Chiral Tetraphenylene Analogues Enabled by NHC\u2010Catalyzed Benzoin Condensation"],"prefix":"10.1002","volume":"65","author":[{"given":"Yuanhang","family":"Zhang","sequence":"first","affiliation":[{"name":"China\u2010New Zealand Belt and Road Joint Laboratory on Biomedicine and Health Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences  Guangzhou People's Republic of China"},{"name":"University of Chinese Academy of Sciences  Beijing People's Republic of 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