{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:55:24Z","timestamp":1790657724170,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Polyglycolide (PGA) is a leading biodegradable polyester, but controlled access to high\u2010molecular\u2010weight PGA remains challenging. Here, we introduce a covalent preorganization strategy that merges H\u2010bond\u2010mediated monomer activation and alkoxide\u2010based chain propagation within a single molecular scaffold. Systematic variation of the H\u2010bond donor, substituent electronics, tether length, and counter cation identifies the thiourea\u2010based sodium alkoxide\n                    <jats:bold>Cat. 7<\/jats:bold>\n                    as an optimal catalyst\/initiator. Under mild conditions,\n                    <jats:bold>Cat. 7<\/jats:bold>\n                    enables rapid and selective ring\u2010opening polymerization of glycolide, affording PGA with number\u2010average molecular weights up to 222.4\u00a0kDa (dispersity of 1.57, turnover number of 11\u00a0600, and turnover frequency of 483\u00a0h\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). Crystallographic, kinetic, spectroscopic, and computational studies support an intramolecular cooperative mechanism. The resulting high\u2010molecular\u2010weight PGA exhibits high crystallinity and tensile strength, highlighting (thio)urea\u2010alkoxide covalent integration as a powerful strategy for the precision synthesis of high\u2010performance biodegradable polyesters.\n                  <\/jats:p>","DOI":"10.1002\/anie.6732152","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:06:43Z","timestamp":1790654803000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Covalently Preorganized (Thio)Urea\u2013Alkoxide Organocatalysts Enable Controlled Synthesis of High\u2010Molecular\u2010Weight Polyglycolide"],"prefix":"10.1002","author":[{"given":"Jianghui","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biobased Transportation Fuel Technology International Research Center For X Polymers Department of Polymer Science and Engineering Zhejiang University  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