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Herein, we report a copper\u2010catalyzed asymmetric deborylative radical coupling enabled by amino radical transfer (ART). By employing aminobenzoates as dual\u2010function reagents, acting both as aminyl radical precursors to trigger ART\u2010mediated homolytic C(sp\n                    <jats:sup>3<\/jats:sup>\n                    )\u2013B bond cleavage and as oxygen nucleophiles, this three\u2010component transformation enables enantioselective coupling of APEs with conjugated dienes. The method delivers structurally diverse chiral allylic esters with excellent enantioselectivities (up to 99% ee). Furthermore, this protocol enables the concise formal synthesis of natural products and the modular construction of chiral ionizable lipids with precise three\u2010dimensional architectures. These lipids achieve enhanced organ\u2010selective mRNA delivery, exhibiting extrahepatic targeting with an improved preference for the spleen. Notably, this work establishes a versatile catalytic platform for transforming bench\u2010stable APEs feedstocks into oxygen\u2010containing chiral molecules, facilitating the development of tissue\u2010specific genetic medicines.\n                  <\/jats:p>","DOI":"10.1002\/anie.6992175","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:02:32Z","timestamp":1780470152000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Copper\u2010Catalyzed Amino Radical Transfer\u2010Mediated Deborylation for Chiral Ester Synthesis"],"prefix":"10.1002","volume":"65","author":[{"given":"Yu\u2010Hang","family":"Peng","sequence":"first","affiliation":[{"name":"Key Laboratory of Anti\u2010Inflammatory and Immune Medicine Ministry of Education School of Pharmacy Anhui Medical University Hefei 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