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Among these, allenes represent a particularly important class of motifs due to their unique structural and electronic properties, yet their catalytic enantioselective construction remains underdeveloped. Here we report a copper\u2010catalyzed enantioselective vinyl boron\u2010Wittig reaction that enables the efficient synthesis of chiral allenes from readily available 1,1\u2010diborylalkenes and aldehydes. This transformation proceeds under mild conditions using earth\u2010abundant copper catalysts and readily accessible ligands, and exhibits a broad substrate scope, encompassing both aryl\u2010 and alkyl\u2010substituted diborylalkenes as well as aromatic and aliphatic aldehydes. The method delivers di\u2010 and tri\u2010substituted chiral allenes in good yields, with high enantioselectivity and excellent functional\u2010group tolerance, and is applicable to structurally complex substrates derived from natural products and pharmaceuticals. The resulting functionalized allenes can be readily diversified, highlighting the synthetic utility of this approach. Mechanistic studies support a pathway involving regioselective transmetalation, enantioselective 1,2\u2010addition, and a copper\u2010promoted B\u2013O elimination, thereby establishing a new paradigm for allene synthesis through a catalytic boron\u2010Wittig\u2010type reaction.<\/jats:p>","DOI":"10.1002\/anie.7084396","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:54:37Z","timestamp":1788926077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enantioselective Copper\u2010Catalyzed Vinyl Boron\u2010Wittig Reaction to Form Allenes"],"prefix":"10.1002","author":[{"given":"Ziwen","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemo and Biosensing College of Chemistry and Chemical Engineering Hunan University  Changsha Hunan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisen","family":"Yao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemo and Biosensing College of Chemistry and Chemical Engineering Hunan University  Changsha Hunan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6313-399X","authenticated-orcid":false,"given":"Wanxiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemo and Biosensing College of Chemistry and Chemical Engineering Hunan University  Changsha Hunan P.R. 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