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Herein, the selective desulfurative deuteration of widely available (hetero)aryl sulfides with D\n                    <jats:sub>2<\/jats:sub>\n                    O (mostly 1.5 or 3.0 equiv.) has been established by nickel catalysis. This strategy affords an efficient and robust route for the synthesis of a wide range of deuterated (hetero)arenes (87 examples, &gt; 10 different heterocycles) in generally good yields and high deuterium incorporation with good functional group compatibility. The catalytic reaction could be applied to scaled\u2010up synthesis (e.g., 6.4\u00a0g for product\n                    <jats:bold>2<\/jats:bold>\n                    , 0.1 mol% Ni catalyst, 590 TON) and late\u2010stage deuteration of various drugs and bioactive molecules.\n                  <\/jats:p>","DOI":"10.1002\/anie.7248763","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:03:16Z","timestamp":1784635396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Desulfurative Deuteration of (Hetero)Aryl Sulfides With D\n                    <sub>2<\/sub>\n                    O by Nickel Catalysis"],"prefix":"10.1002","volume":"65","author":[{"given":"Yaqi","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), Key Laboratory of Phytochemical R&amp;D of Hunan Province, and 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