{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:18:42Z","timestamp":1790997522572,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22274072"],"award-info":[{"award-number":["22274072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22174043"],"award-info":[{"award-number":["22174043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20242022"],"award-info":[{"award-number":["BK20242022"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2024300408"],"award-info":[{"award-number":["2024300408"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011400","name":"State Key Laboratory of Analytical Chemistry for Life Science","doi-asserted-by":"publisher","award":["5431ZZXM2505"],"award-info":[{"award-number":["5431ZZXM2505"]}],"id":[{"id":"10.13039\/501100011400","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,7,13]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mitochondrial iron redox homeostasis plays critical roles in cellular function and disease progression; however, spatiotemporal measurement of Fe\n                    <jats:sup>2+<\/jats:sup>\n                    and Fe\n                    <jats:sup>3+<\/jats:sup>\n                    dynamics in mitochondria remains challenging, largely due to limited analytical tools. Here we report a light\u2010inducible bispecific DNAzyme sensor (LiBD) that enables simultaneous and spatiotemporally controlled imaging of mitochondrial labile Fe\n                    <jats:sup>2+<\/jats:sup>\n                    and Fe\n                    <jats:sup>3+<\/jats:sup>\n                    in living cells and in vivo. LiBD integrated two orthogonal iron\u2010specific DNAzymes into a single DNA scaffold, incorporating photocleavable (PC) linkers, rendering DNAzymes inactive until light\u2010triggered activation. Coupled with mitochondria\u2010targeted nanocarriers, LiBD demonstrated high spatial and temporal resolution for monitoring Fe\n                    <jats:sup>2+<\/jats:sup>\n                    and Fe\n                    <jats:sup>3+<\/jats:sup>\n                    level changes in mitochondria. We revealed remarkable mitochondrial Fe\n                    <jats:sup>2+<\/jats:sup>\n                    accumulation in tumor cells during drug\u2010induced ferroptosis, whereas chemotherapy\u2010resistant tumor cells exhibited substantially decreased Fe\n                    <jats:sup>2+<\/jats:sup>\n                    in mitochondria, both accompanied by slight increases in Fe\n                    <jats:sup>3+<\/jats:sup>\n                    . Moreover, an NIR\u2010activatable LiBD demonstrated in vivo visualization of mitochondrial Fe\n                    <jats:sup>2+<\/jats:sup>\n                    and Fe\n                    <jats:sup>3+<\/jats:sup>\n                    level changes during ferroptosis in tumor\u2010bearing mice. Collectively, this work presents LiBD as a powerful platform for investigating mitochondrial iron biology with spatiotemporal precision and provides insights into iron\u2010dependent mechanisms of ferroptosis and chemoresistance.\n                  <\/jats:p>","DOI":"10.1002\/anie.7378442","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T13:34:07Z","timestamp":1779456847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Light\u2010Inducible Bispecific DNAzymes Reveal Mitochondrial Fe\n                    <sup>2+<\/sup>\n                    \/Fe\n                    <sup>3+<\/sup>\n                    Dynamics During Ferroptosis"],"prefix":"10.1002","volume":"65","author":[{"given":"Yang","family":"Shi","sequence":"first","affiliation":[{"name":"State Key Laboratory of Analytical Chemistry For Life Science School of Chemistry Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemo and Biosensing College of Chemistry and Chemical Engineering Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Analytical Chemistry For Life Science School of Chemistry Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3917-8343","authenticated-orcid":false,"given":"Hang","family":"Xing","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemo and Biosensing College of Chemistry and Chemical Engineering Hunan University  Changsha 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