{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:41:53Z","timestamp":1793032913855,"version":"4.5.0"},"reference-count":66,"publisher":"Wiley","issue":"44","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32502359"],"award-info":[{"award-number":["32502359"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32603582"],"award-info":[{"award-number":["32603582"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFF1102400"],"award-info":[{"award-number":["2022YFF1102400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M780895"],"award-info":[{"award-number":["2025M780895"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,10,26]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Escalating antimicrobial resistance and declining antibiotic efficacy spur interest in photocatalytic antibacterial therapies. Covalent organic frameworks (COFs) are promising photodynamic antibacterial agents, though rapid carrier recombination, low reactive oxygen species (ROS) yields, and poor photostability remain constraints. Herein, we report the successful synthesis of two large\u2010pore [8+2] 3D\u2010bcu\u2010COFs. SEU\u2010301 was constructed from an 8\u2010connected porphyrin building unit and a linear tetraphenyl linker. Introducing a linear side\u2010chain bis(benzothiadiazole) linker via three\u2010component functional modulation afforded SEU\u2010302, which enhances light absorption, accelerates charge separation, and suppresses carrier recombination, thereby extending the excited\u2010state lifetime\u2014confirmed by femtosecond transient absorption spectroscopy (fs\u2010TAS) and density functional theory (DFT) calculations. Further proteomic analysis shows that the ROS efficiently generated by light\u2010activated SEU\u2010302 elicit membrane damage and homeostatic imbalance, precipitating a cascade of stress responses that culminate in metabolic dysregulation, while also synergistically combating bacteria and inflammation. The therapeutic potential was further validated in vitro and in vivo, where light\u2010activated SEU\u2010302 not only effectively eliminated\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and inhibited its proliferation, but also promoted wound healing with increased collagen deposition and hair follicle regeneration. Results identify 3D COFs as very promising materials for both photodynamic therapies and antibacterial therapies.\n                  <\/jats:p>","DOI":"10.1002\/anie.7443715","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:29:56Z","timestamp":1788776996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Large\u2010Pore 3D Covalent Organic Frameworks with Light\u2010Sensitized Synergy for Efficient Photocatalytic Antibacterial Therapies and Wound Healing"],"prefix":"10.1002","volume":"65","author":[{"given":"Pengfei","family":"Dong","sequence":"first","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering Ministry of Education Department of Nutrition and Food Hygiene School of Public Health Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering Ministry of Education Department of Nutrition and Food Hygiene School of Public Health Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering Ministry of Education Department of Nutrition and Food Hygiene School of Public Health Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4874-4215","authenticated-orcid":false,"given":"Jing","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering Ministry of Education Department of Nutrition and Food Hygiene School of Public Health Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7340-8769","authenticated-orcid":false,"given":"Wenshuai","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering Ministry of Education Department of Nutrition and Food Hygiene School of Public Health Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1266-9583","authenticated-orcid":false,"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering Ministry of Education Department of Nutrition and Food Hygiene School of Public Health Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6181-2294","authenticated-orcid":false,"given":"Muhammad","family":"Waqas","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering Ministry of Education Department of Nutrition and Food Hygiene School of Public Health Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1819-6710","authenticated-orcid":false,"given":"Vijaya","family":"Raghavan","sequence":"additional","affiliation":[{"name":"Department of Bioresource Engineering McGill University  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3296-3093","authenticated-orcid":false,"given":"Geoffrey I. N.","family":"Waterhouse","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences The University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3117-9173","authenticated-orcid":false,"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering Ministry of Education Department of Nutrition and Food Hygiene School of Public Health Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav6390"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c02324"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010021\u201000362\u20104"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820\u2010020\u201000485\u20103"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c10200"},{"key":"e_1_2_8_7_1","first-page":"0893","article-title":"Intrathecal Antibacterial and Antifungal Therapies","volume":"33","author":"Nau R.","year":"2020","journal-title":"Clinical Microbiology Reviews Kim"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.07.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c12714"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222\u2010023\u201000119\u20104"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202200799"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202005477"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103721"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c11628"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2025.147471"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2025.217453"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202002046"},{"key":"e_1_2_8_18_1","article-title":"Metformin\u2010Based Covalent Organic Frameworks With Excellent Biosafety and High Efficiency against Pathogenic Microorganisms","volume":"13","author":"Liu J.","year":"2026","journal-title":"Advancement of Science"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c03519"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201907242"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202314763"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202311519"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11426\u2010020\u20109836\u2010x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202012487"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202002090"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100775"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202411237"},{"key":"e_1_2_8_28_1","article-title":"Antibacterial activity of guanidinium\u2010based ionic covalent organic framework anchoring Ag nanoparticles","volume":"435","author":"Zhang H.","year":"2022","journal-title":"Advanced Healthcare Material"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.163995"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202408959"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202505669"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201041622\u2010x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202513754"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202405313"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202502220"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202413311"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202409925"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c07733"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c11893"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c03897"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c11300"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202117661"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202307991"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c09559"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c06986"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202502220"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c12339"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201028409\u20102"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c10627"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201060960\u20106"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201055894\u2010y"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040991\u20107"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201806551"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202420643"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2407012121"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2020.100024"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202406026"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c03060"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202115956"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202408918"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c02825"},{"key":"e_1_2_8_62_1","article-title":"Self\u2010Adaptive Allantoin@ZIF8 Nanocomposite Hydrogel With Resveratrol Synergy for MRSA\u2010Infected Wound Regeneration","volume":"13","author":"Zhu Y.","year":"2026","journal-title":"Advancement of Science"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202506505"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c07262"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.72911"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2423052122"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202531945"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.7443715","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.7443715","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.7443715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:27:38Z","timestamp":1793032058000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.7443715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,7]]},"references-count":66,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2026,10,26]]}},"alternative-id":["10.1002\/anie.7443715"],"URL":"https:\/\/doi.org\/10.1002\/anie.7443715","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,7]]},"assertion":[{"value":"2026-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7443715"}}