{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:26:04Z","timestamp":1787855164869,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52503260"],"award-info":[{"award-number":["52503260"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22303034"],"award-info":[{"award-number":["22303034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Polymer networks possess numerous elastically defective and isolated loops, which do not contribute to mechanical stiffness. In this report, we introduce a strategy of supramolecular topological linking to access stiffer\u2010yet\u2010ductile polymeric materials through incorporation of supramolecular tetravalent crosslinkers. Dynamic dissociation\/re\u2010association between these high\u2010functionality crosslinks enables the formation of topologically\u2010linked loops that serve as elastic springs to stiffen the networks. An exceptional scaling exponent of 2.05 for Young's modulus versus crosslinker concentration is obtained, exceeding most reported randomly\u2010crosslinked polymeric systems. Compared to conventional analogs, the mechanical properties of the resultant materials are enhanced: Young's modulus (2\u2010fold), elongation at break (8\u2010fold), and work of fracture (100\u2010fold). Uplifting modulus scalings through supramolecular topological linking paves a new path to the design of stiffness\u2010reinforced soft materials, holding substantial promise in load\u2010bearing application scenarios such as tissue implants, bioelectronic interfaces, and soft robotics.<\/jats:p>","DOI":"10.1002\/anie.7480690","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:16:35Z","timestamp":1776687395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stiffness Reinforcement in Polymer Networks Through Supramolecular Topological Linking"],"prefix":"10.1002","volume":"65","author":[{"given":"Bohang","family":"Wu","sequence":"first","affiliation":[{"name":"Key Laboratory of Polymer Chemistry and Physics of Ministry of Education School of Materials Science and Engineering Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junting","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polymer Chemistry and Physics of Ministry of Education School of Materials Science and Engineering Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polymer Chemistry and Physics of Ministry of Education School of Materials Science and Engineering Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Research School of Polymeric Materials, School of Materials Science and Engineering Jiangsu University Zhenjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Ding","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polymer Chemistry and Physics of Ministry of Education School of Materials Science and Engineering Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du","family":"Wang","sequence":"additional","affiliation":[{"name":"Arthritis Clinical and Research Center Peking University People's Hospital  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhou","family":"Wang","sequence":"additional","affiliation":[{"name":"Arthritis Clinical and Research Center Peking University People's Hospital  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polymer Chemistry and Physics of Ministry of Education School of Materials Science and Engineering Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polymer Chemistry and Physics of Ministry of Education School of Materials Science and Engineering Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinling","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polymer Chemistry and Physics of Ministry of Education School of Materials Science and Engineering Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Arthritis Clinical and Research Center Peking University People's Hospital  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6966-3134","authenticated-orcid":false,"given":"Dan","family":"Xing","sequence":"additional","affiliation":[{"name":"Arthritis Clinical and Research Center Peking University People's Hospital  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1830-9244","authenticated-orcid":false,"given":"Jianhao","family":"Lin","sequence":"additional","affiliation":[{"name":"Arthritis Clinical and Research Center Peking University People's Hospital  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Pritzker School of Molecular Engineering The University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9604-7764","authenticated-orcid":false,"given":"Yuwei","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology Rutgers The State University of New Jersey  Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixian","family":"Lv","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polymer Chemistry and Physics of Ministry of Education School of Materials Science and Engineering Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchong","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polymer Chemistry and Physics of Ministry of Education School of Materials Science and Engineering Peking University Beijing China"},{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jiao","sequence":"additional","affiliation":[{"name":"College of Chemistry and Molecular Engineering Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanglu","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-8322","authenticated-orcid":false,"given":"Jasper","family":"van der Gucht","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Chemistry and Soft Matter Wageningen University &amp; Research  Wageningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martien A. Cohen","family":"Stuart","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Chemistry and Soft Matter Wageningen University &amp; Research  Wageningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongfan","family":"Hao","sequence":"additional","affiliation":[{"name":"Research School of Polymeric Materials, School of Materials Science and Engineering Jiangsu University Zhenjiang China"},{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4111-7064","authenticated-orcid":false,"given":"Zehuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polymer Chemistry and Physics of Ministry of Education School of Materials Science and Engineering Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adq6434"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006520\u20108"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010024\u201000672\u20103"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adh3632"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010022\u201001195\u20104"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2023.05.042"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.ado1782"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010021\u201000412\u2010x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.023.202303460"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adg3229"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal4373"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010018\u20100339\u20100"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006037\u20100"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44160\u2010025\u201000791\u2010x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg6320"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780198520597.001.0001"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma60075a033"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00800"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010conmatphys\u2010033117\u2010054235"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adr9713"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21075"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c11718"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010024\u201001580\u20103"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap7675"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.4c00006"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02770756"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010024\u201002091\u20109"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag0184"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010023\u201001663\u20105"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.106.167802"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma300942a"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja993376p"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200460675"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijch.201100035"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cs60261c"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00273C"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00341"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2023.101309"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201605325"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10118\u2010024\u20103204\u20107"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201030021\u20103"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202002008"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2492"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja500205v"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.9b00238"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1122\/8.0000043"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202105112"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010021\u201001124\u2010x"},{"key":"e_1_2_8_50_1","unstructured":"ISO Biological Evaluation of Medical Devices\u2014Part 12: Sample Preparation and Reference Materials(International Organization for Standardization 2021) ISO 109993\u201012."},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj7564"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.7480690","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.7480690","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.7480690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:15:10Z","timestamp":1787854510000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.7480690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":50,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.1002\/anie.7480690"],"URL":"https:\/\/doi.org\/10.1002\/anie.7480690","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]},"assertion":[{"value":"2026-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7480690"}}