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In this work, we present a strategy to activate intermolecular excited\u2010state PT within the hydrophobic cavities of cyclodextrin\u2010based nanotubes. Activation is achieved using a specifically designed amphoteric emitter which undergoes a pKa inversion in the photoexcited state. Despite this photophysical behavior, intramolecular PT does not occur due to the spatial separation between the proton donor and acceptor sites in the compound. However, in the presence of \u03b3\u2010cyclodextrin, the photoacid assembles into guest pairs, enabling pre\u2010organized PT between neighboring molecules. The effects of confinement on photostability, emission lifetime, and quantum yield indicate a mechanistic shift from excited\u2010state protolytic dissociation to intermolecular excited\u2010state PT. Spectroscopic investigation of the assembly mechanism and solvent isotope effect further supports the role of a template effect, reminiscent of enzymatic activation, in facilitating PT in the excited state.<\/jats:p>","DOI":"10.1002\/anie.7594145","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:57:36Z","timestamp":1780966656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Redirecting Excited\u2010State Proton Transfer Through Supramolecular Polymerization in Nanoconfinement"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5399-6137","authenticated-orcid":false,"given":"Luis C.","family":"Pantaleone","sequence":"first","affiliation":[{"name":"Stratingh Institute for Chemistry University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Hutchings","sequence":"additional","affiliation":[{"name":"Stratingh Institute for Chemistry University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente","family":"Reus","sequence":"additional","affiliation":[{"name":"Stratingh Institute for Chemistry University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Stratingh Institute for Chemistry University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6793-5845","authenticated-orcid":false,"given":"Alessia","family":"Lasorsa","sequence":"additional","affiliation":[{"name":"Zernike Institute for Advanced Materials University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5390-3321","authenticated-orcid":false,"given":"Patrick C. 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