{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:43:49Z","timestamp":1793036629232,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"44","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003071","name":"Adolphe Merkle Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,10,26]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Mechanochromic hydrogels that report deformation through optical signals require mechanophores that function in aqueous environments, are activated at low force, and allow integration into the hydrogel matrix. Here, we report a new strategy to address these challenges that involves deploying a supramolecular mechanophore as a water\u2010soluble macromolecular additive. The mechanophore developed for this purpose features a loop\u2010forming architecture, in which a naphthalene diimide (NDI) quencher and a 9,10\u2010bis(phenylethynyl)anthracene (BPEA) fluorophore are connected by a short spacer. Intramolecular charge\u2010transfer interactions between these moieties induce loop formation and quench the BPEA emission. Mechanical deformation unfolds the loop, disrupts the charge\u2010transfer interaction, and increases the BPEA emission. The functionalization of this loop\u2010forming motif with poly(oligo(ethylene glycol) methyl ether methacrylate) (pOEGMA) affords a macromolecular water\u2010soluble additive that can simply be blended into different hydrogel matrices, including cross\u2010linked poly(acrylamide) and pOEGMA. These hydrogels exhibit a pronounced increase in emission intensity upon swelling, stretching, and compression. Spectroscopic investigations reveal correlations between the applied deformation and the optical response and show that the mechanophore activation is fully reversible. The results establish macromolecular supramolecular mechanophores as a general strategy for imparting reversible mechanochromism to hydrogels.<\/jats:p>","DOI":"10.1002\/anie.7699472","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:28:54Z","timestamp":1788776934000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Supramolecular Mechanophore Additives Enable Mechanochromic Hydrogels"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3706-2108","authenticated-orcid":false,"given":"Iulia","family":"Scarlat","sequence":"first","affiliation":[{"name":"Adolphe Merkle Institute (AMI) University of Fribourg  Fribourg Switzerland"},{"name":"NCCR Bio\u2010inspired Materials University of Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3701-7829","authenticated-orcid":false,"given":"Jess M.","family":"Clough","sequence":"additional","affiliation":[{"name":"Adolphe Merkle Institute (AMI) University of Fribourg  Fribourg Switzerland"},{"name":"NCCR Bio\u2010inspired Materials University of Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7183-1790","authenticated-orcid":false,"given":"Christoph","family":"Weder","sequence":"additional","affiliation":[{"name":"Adolphe Merkle Institute (AMI) University of Fribourg  Fribourg Switzerland"},{"name":"NCCR Bio\u2010inspired Materials University of Fribourg  Fribourg 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