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With the prevalence of antimicrobial\u2010resistant\n                    <jats:italic>Salmonella<\/jats:italic>\n                    , vaccines are urgently needed to prevent and reduce infections. There are no vaccines available against any non\u2010typhoidal\n                    <jats:italic>Salmonella<\/jats:italic>\n                    (NTS) serovars, including two of the most common ones, that are,\n                    <jats:italic>Salmonella<\/jats:italic>\n                    Typhimurium and\n                    <jats:italic>Salmonella<\/jats:italic>\n                    Enteritidis. While traditional\n                    <jats:italic>Salmonella<\/jats:italic>\n                    vaccine approaches require a construct against each serotype, a new strategy has been developed in this work targeting the shared O\u2010polysaccharide backbone as a potential common vaccine antigen. Tri\u2010, hexa\u2010, and nona\u2010saccharides corresponding to one to three repeating units of the O\u2010polysaccharide backbone were synthesized stereoselectively via a modular approach. These oligosaccharides were conjugated to the bacteriophage Q\u03b2 carrier, which elicited strong IgG responses against the synthetic carbohydrate antigens upon immunization of both mice and rabbits. The trisaccharide antigen was sufficient to induce protective antibodies. The post\u2010immune sera from Q\u03b2\u2010trisaccharide immunized rabbits recognized the native O\u2010polysaccharides from both\n                    <jats:italic>S<\/jats:italic>\n                    . Typhimurium and\n                    <jats:italic>S<\/jats:italic>\n                    . Enteritidis, and significantly protected mice against lethal challenges by these\n                    <jats:italic>Salmonella<\/jats:italic>\n                    serotypes. The ability of a single glycan antigen to protect against infections by two different NTS serovars is a significant step forward for broad\u2010spectrum anti\u2010\n                    <jats:italic>Salmonella<\/jats:italic>\n                    vaccine design.\n                  <\/jats:p>","DOI":"10.1002\/anie.7740689","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T10:34:13Z","timestamp":1778150053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synthetic O\u2010Polysaccharide Backbone Units for a Single Antigen Vaccine Against Two Major Non\u2010Typhoidal\n                    <i>Salmonella<\/i>\n                    Serovars"],"prefix":"10.1002","volume":"65","author":[{"given":"Xingling","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Chemistry Michigan State University  East Lansing Michigan USA"},{"name":"Institute For Quantitative Health Science &amp; Engineering Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxin","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Chemistry Michigan State University  East Lansing Michigan USA"},{"name":"Institute For Quantitative Health Science &amp; Engineering Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soham","family":"Maity","sequence":"additional","affiliation":[{"name":"Iaso Therapeutics Inc.  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