{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:56:17Z","timestamp":1791226577798,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"41","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22425401"],"award-info":[{"award-number":["22425401"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373115"],"award-info":[{"award-number":["82373115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274312"],"award-info":[{"award-number":["82274312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574010"],"award-info":[{"award-number":["82574010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Stem cell\u2010derived extracellular vesicles (EVs) have emerged as promising therapeutics for wound healing, yet their clinical applications are limited by rapid clearance and poor retention at wound sites. Conventional delivery systems rely on preformed biomaterials and passive release, which cannot adapt to the dynamic wound environments and provide precise temporal control over EVs availability. Here, we present an in situ forming adhesive hydrogel that enables 405\u00a0nm light\u2010triggered gelation at the acute wound surfaces directly and near\u2010infrared (NIR) light\u2010stimulated on\u2010demand release of EVs. This hydrogel integrates EVs within a biocompatible polymer matrix, forming a conformal, shape\u2010adaptable scaffold that can seamlessly cover wounds with irregular geometries. In vitro studies demonstrated NIR\u2010responsive EVs release and preserved bioactivity. In vivo experiments using acute wound models (full\u2010thickness excision and deep second\u2010degree burn) showed dramatically accelerated tissue regeneration, enhanced angiogenesis, and reduced scar formation compared with EVs\u2010only or hydrogel\u2010only treatments. Overall, this work introduces a versatile, multifunctional platform for spatiotemporal EVs delivery, offering new strategies for effective wound repair.<\/jats:p>","DOI":"10.1002\/anie.7741887","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:51:16Z","timestamp":1786636276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatiotemporal Delivery of Stem Cell\u2010Derived Extracellular Vesicles for Rapid Wound Healing"],"prefix":"10.1002","volume":"65","author":[{"given":"Jingjing","family":"Kang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, and Frontiers Science Center for New Organic Matter, College of Chemistry Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, and Frontiers Science Center for New Organic Matter, College of Chemistry Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingqi","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, and Frontiers Science Center for New Organic Matter, College of Chemistry Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, and Frontiers Science Center for New Organic Matter, College of Chemistry Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshuai","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory For Crop Stress Resistance and High\u2010Efficiency Production, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0618-5985","authenticated-orcid":false,"given":"Rui","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, and Frontiers Science Center for New Organic Matter, College of Chemistry Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, and Frontiers Science Center for New Organic Matter, College of Chemistry Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, and Frontiers Science Center for New Organic Matter, College of Chemistry Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, and Frontiers Science Center for New Organic Matter, College of Chemistry Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Yang","sequence":"additional","affiliation":[{"name":"The Hospital of Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Dermatology Air Force Medical Center, PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Air Force Medical Center, PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-9822","authenticated-orcid":false,"given":"Dingbin","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, and Frontiers Science Center for New Organic Matter, College of Chemistry Nankai University  Tianjin China"},{"name":"Department of Radiology Tianjin Medical University Cancer Institute and Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202107960"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010024\u201001035\u2010z"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.148347"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.06.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12099"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300556"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u2010475X.2009.00543.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh4327"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200223"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000265074.83288.09"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14836"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003920"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929\u2010021\u201000725\u20107"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010021\u201002697\u20109"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201504009"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2021.1951896"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100477"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202104165"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010018\u20100319\u20104"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ado9479"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.3c04669"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201104797"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.106579"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010023\u201000670\u20100"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf4568"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.energy.2017.09.059"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201801000"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.126182"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.133859"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.02.010"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.11.012"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201003963"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.08.089"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2022.124696"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.10.040"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10570\u2010018\u20102015\u20109"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl304478h"},{"key":"e_1_2_9_39_1","article-title":"Mussel\u2010Inspired Adhesive Bilayer Hydrogels for Bacteria\u2010Infected Wound Healing","volume":"210","author":"Duan Q.","year":"2022","journal-title":"Colloid Surface B"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh4327"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c10575"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011074915438"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.2217\/17435889.2.6.789"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2017.01.021"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222010952"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.05.015"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.11.036"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c00204"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.146092"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62020-5"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201900046"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202304023"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.05.001"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202207437"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.07.016"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB00822F"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201047696\u20105"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-023-00472-w"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.10.022"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122789"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf7207"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202303642"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2014\u20100267"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015\u2010020\u201009992\u20107"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103610"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.3c00352"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vesic.2024.100049"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2014.02.007"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04556"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122558"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202200314"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39129-6"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201909125"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.7741887","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.7741887","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.7741887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:46:41Z","timestamp":1791226001000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.7741887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":72,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2026,10,5]]}},"alternative-id":["10.1002\/anie.7741887"],"URL":"https:\/\/doi.org\/10.1002\/anie.7741887","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"assertion":[{"value":"2026-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7741887"}}