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The introduction of deuterium or\n                    <jats:sup>13<\/jats:sup>\n                    C atoms can enable the direct tracing of the drug molecule without substantially altering its structure or function, and the introduction of CD\n                    <jats:sub>3<\/jats:sub>\n                    \u2010 or\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010labeled methyl into drug molecules is one of the most commonly employed methodology. However, the key issue that plagues the current research area is the lack of highly efficient, cheap and practical reagent. Herein, methyl\u2010d\n                    <jats:sub>3<\/jats:sub>\n                    \u2010\n                    <jats:italic>N,N'<\/jats:italic>\n                    \u2010diisopropylcarbamimidate (MDIC\u2010d\n                    <jats:sub>3<\/jats:sub>\n                    ), methyl\u2010\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010\n                    <jats:italic>N,N'<\/jats:italic>\n                    \u2010diisopropylcarbamimidate (MDIC\u2010\n                    <jats:sup>13<\/jats:sup>\n                    C) and methyl\u2010\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010d\n                    <jats:sub>3<\/jats:sub>\n                    \u2010\n                    <jats:italic>N,N'<\/jats:italic>\n                    \u2010diisopropylcarbamimidate (MDIC\u2010\n                    <jats:sup>13<\/jats:sup>\n                    CD\n                    <jats:sub>3<\/jats:sub>\n                    ), synthesized via reaction of diisopropylcarbodiimide with the corresponding stable isotope labelled methanols, have been developed for the efficient\n                    <jats:italic>d<\/jats:italic>\n                    <jats:sub>3<\/jats:sub>\n                    \u2010methylation,\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010methylation and\n                    <jats:sup>13<\/jats:sup>\n                    CD\n                    <jats:sub>3<\/jats:sub>\n                    \u2010methylation of complex molecules bearing several possible reactive sites with good selectivity, high\u2010level deuterium and\n                    <jats:sup>13<\/jats:sup>\n                    C incorporation, and good functional group tolerance under external base\u2010free conditions. Additionally, these reagents can also be employed for the highly efficient isotope\u2010labeled methylation of arenes via palladium\u2010catalyzed Suzuki\u2013Miyaura type cross\u2010coupling.\n                  <\/jats:p>","DOI":"10.1002\/anie.7843825","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T17:57:32Z","timestamp":1785088652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isotope\u2010Labeled Methanol\u2010Derived\n                    <i>O<\/i>\n                    \u2010Alkylisoureas as Versatile and Practical Agents for d\n                    <sub>3<\/sub>\n                    \u2010Methylation,\n                    <sup>13<\/sup>\n                    C\u2010Methylation, and\n                    <sup>13<\/sup>\n                    CD\n                    <sub>3<\/sub>\n                    \u2010Methylation"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5110-0442","authenticated-orcid":false,"given":"Weikang","family":"Xiong","sequence":"first","affiliation":[{"name":"Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Institute of New Concept Sensors and Molecular Materials, and School of Chemistry and Chemical Engineering Shaanxi Normal University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Institute of New Concept Sensors and Molecular Materials, and School of Chemistry and Chemical Engineering Shaanxi Normal University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Liu","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiameng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Institute of New Concept Sensors and Molecular Materials, and School of Chemistry and Chemical Engineering Shaanxi Normal University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4616-5578","authenticated-orcid":false,"given":"Tengfei","family":"Kang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Institute of New Concept Sensors and Molecular Materials, and School of Chemistry and Chemical Engineering Shaanxi Normal University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7269-6356","authenticated-orcid":false,"given":"Dong","family":"Xue","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Institute of New Concept Sensors and Molecular Materials, and School of Chemistry and Chemical Engineering Shaanxi Normal University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201303207"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00628G"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200060g"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm3003697"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.1c02010"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00973C"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2019.12.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b00765"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00544H"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01808"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm4007998"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.47287\/cen\u201010104\u2010buscon1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0617\u2010493"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20103015\u20100"},{"key":"e_1_2_8_16_1","unstructured":"T. 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