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Consequently, developing effective strategies for constructing biocompatible, long\u2010wavelength emissive, and intrinsically selective bioprobes has long been a central goal in chemistry. Herein, we develop a stepwise assembly protocol to construct an exotic cage\u2010in\u2010rings bioimaging probe,\n                    <jats:bold>\n                      TPBCage\n                      <jats:sup>6+<\/jats:sup>\n                      \u22823CB[8]\n                    <\/jats:bold>\n                    , through noncovalent association of a hexacationic cage (TPBCage\n                    <jats:sup>6+<\/jats:sup>\n                    ) with cucurbit[8]uril (CB[8]). The complex adopts a thermodynamically favored\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    \u2010symmetrical conformation rather than the expected\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>3<\/jats:sub>\n                    \u2010symmetrical analogue. It preserves two exposed pyridinium units, providing a structural basis for efficient cellular uptake, while the other four pyridinium units are partially shielded by CB[8], reducing nonspecific interactions in bioimaging to some extent compared with the free cage. Encapsulation by CB[8] effectively suppresses \u03c0\u2013\u03c0 stacking of the cage, improving its aqueous solubility. Concomitantly, CB[8] encapsulation narrows the energy gap of the cage, resulting in a red shift in emission from 552 to 652\u00a0nm and an enhanced fluorescence quantum yield. Benefiting from enhanced water solubility, good biocompatibility, and deep\u2010red emission, the complex enables lysosome\u2010selective imaging in deep\u2010red region. This work establishes an alternative supramolecular strategy for subcellular\u2010selective imaging, in which cage\u2010in\u2010rings confinement enables control over excited\u2010state properties, enabling the development of intrinsically selective bioimaging probes.\n                  <\/jats:p>","DOI":"10.1002\/anie.7910152","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:58:17Z","timestamp":1782820697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Deep\u2010Red Emissive Cage\u2010in\u2010Rings Complex for Lysosome Imaging"],"prefix":"10.1002","volume":"65","author":[{"given":"Hui\u2010Juan","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Materials for Intelligent Sensing Key Laboratory of Organic Integrated Circuit Department of Chemistry School of Science Ministry of Education &amp; Tianjin Key Laboratory of Molecular 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&amp; Department of Chemistry The University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Song","sequence":"additional","affiliation":[{"name":"Center For Functional Organic Materials Yongjiang Laboratory  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1390-1823","authenticated-orcid":false,"given":"Xianyin","family":"Dai","sequence":"additional","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Taian Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Dou","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology School of Energy Science and Technology Liaocheng University  Liaocheng, Shandong 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