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Inspired by the cooperative electron and proton management in cytochrome c oxidase, we report an\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010MoC\/Fe\u2013N\n                    <jats:sub>4<\/jats:sub>\n                    catalyst in which\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010MoC nanoparticles are interfaced with Fe\u2013N\n                    <jats:sub>4<\/jats:sub>\n                    single\u2010atom sites on a nitrogen\u2010doped carbon scaffold. The\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010MoC component plays a dual role: it withdraws electron density from Fe sites to weaken oxygen\u2010intermediate adsorption and promotes water dissociation to provide local protons for *OH\u2010to\u2010H\n                    <jats:sub>2<\/jats:sub>\n                    O conversion. As a result,\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010MoC\/Fe\u2013N\n                    <jats:sub>4<\/jats:sub>\n                    exhibits a 2.8\u2010fold higher\n                    <jats:italic>V<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    for O\n                    <jats:sub>2<\/jats:sub>\n                    activation than Fe\u2013N\n                    <jats:sub>4<\/jats:sub>\n                    and proceeds through a nearly four\u2010electron oxygen reduction pathway with negligible reactive oxygen species (ROS) generation. This interfacial strategy is generalizable to various M\u2013N\u2013C single\u2010atom catalysts, including Mn, Co, Ni, Cu, Sn, Ir, and Pt. Enabled by efficient O\n                    <jats:sub>2<\/jats:sub>\n                    activation,\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010MoC\/Fe\u2013N\n                    <jats:sub>4<\/jats:sub>\n                    depolymerizes native birch lignin under mild alkaline conditions, substantially decreasing its molecular weight and cleaving\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2013O\u20134,\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2013\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , and\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u20135 linkages. This work establishes an electron\u2010proton dual\u2010modulation strategy for constructing high\u2010performance single\u2010atom catalysts for biomass conversion.\n                  <\/jats:p>","DOI":"10.1002\/anie.7938626","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:03:49Z","timestamp":1791374629000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interfacial Electron\u2013Proton Dual Modulation of Fe Single\u2010Atom Catalyst by\n                    <i>\u03b1<\/i>\n                    \u2010MoC for O\n                    <sub>2<\/sub>\n                    Activation and Lignin Depolymerization"],"prefix":"10.1002","author":[{"given":"Ran","family":"Shi","sequence":"first","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry, School of Chemistry and Materials Science University of Science and Technology of China  Hefei Anhui China"},{"name":"Deep Space Exploration Laboratory University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8087-8440","authenticated-orcid":false,"given":"Jinghang","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry, School of Chemistry and Materials Science University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Song","sequence":"additional","affiliation":[{"name":"Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, School of Chemistry and Materials Science Nanjing Normal University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qichen","family":"Liu","sequence":"additional","affiliation":[{"name":"National Synchrotron Radiation Laboratory University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjing","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry, School of Chemistry and Materials Science University of Science and Technology of China  Hefei Anhui China"},{"name":"Deep Space Exploration Laboratory University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry, School of Chemistry and Materials Science University of Science and Technology of China  Hefei Anhui China"},{"name":"Deep Space Exploration Laboratory University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Anhui Bioatom Technologies Co. 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