{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:21:22Z","timestamp":1787721682594,"version":"build-2784847793"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2020CBEYHC AStraLI"],"award-info":[{"award-number":["2020CBEYHC AStraLI"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Self\u2010assembly is a well\u2010known phenomenon in nature, occurring at all scales, from small molecules to complex biomolecules, and it is the foundation for the formation of hierarchical biological structures. Pivotal is the requirement for precise organization through supramolecular interactions, which often trigger dramatic changes in reactivity, spectroscopic features and functional outcomes. Here, we demonstrate that the self\u2010assembly of a Pt(II) complex not only gives rise to a superior imaging probe, but also to the emergence of redox\u2010active features. Once in vivo, the self\u2010assembled Pt(II) complex surprisingly acts as a potent promoter of stem cell proliferation and a modulator of key physiological functions. The assembled luminescent complexes finely tune reactive oxygen species (ROS) response in the transparent freshwater polyp\n                    <jats:italic>Hydra vulgaris<\/jats:italic>\n                    , enhancing the total antioxidant capacity and modulating the expression of key genes involved in antioxidant defenses and cell cycle progression. In addition, in the sea anemone\n                    <jats:italic>Nematostella vectensis<\/jats:italic>\n                    , the assembled complex accelerates the larvae\u2010to\u2010adult metamorphosis process, further underscoring its multifaceted role and species\u2010specific action in diverse biological systems and ultimately paving the way for innovative theranostic strategies.\n                  <\/jats:p>","DOI":"10.1002\/anie.7957354","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:58:41Z","timestamp":1787720321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Self\u2010Assembled Pt(II) Complexes Boost Up Stem Cell Proliferation and Accelerate Metamorphosis in Living Organisms"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6604-0097","authenticated-orcid":false,"given":"Giuseppina","family":"Tommasini","sequence":"first","affiliation":[{"name":"Istituto Di Scienze Applicate e Sistemi Intelligenti \u201cE.Caianiello\u201d National Research Council  Pozzuoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6419-599X","authenticated-orcid":false,"given":"Tania","family":"Pecoraro","sequence":"additional","affiliation":[{"name":"Dipartimento Di Scienze Farmaceutiche Universit\u00e0 Degli Studi di Milano  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8055-1918","authenticated-orcid":false,"given":"Anna","family":"Lewinska","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology Collegium Medicum, University of Rzeszow  Rzeszow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8518-6670","authenticated-orcid":false,"given":"Maciej","family":"Wnuk","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology Collegium Medicum, University of Rzeszow  Rzeszow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3034-8483","authenticated-orcid":false,"given":"Olga","family":"Kolodziej","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology Collegium Medicum, University of Rzeszow  Rzeszow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5256-3188","authenticated-orcid":false,"given":"Daniela","family":"Intartaglia","sequence":"additional","affiliation":[{"name":"Istituto Di Scienze Applicate e Sistemi Intelligenti \u201cE.Caianiello\u201d National Research Council  Pozzuoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Morgera","sequence":"additional","affiliation":[{"name":"Istituto Di Scienze Applicate e Sistemi Intelligenti \u201cE.Caianiello\u201d National Research Council  Pozzuoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2647-9967","authenticated-orcid":false,"given":"Alessandro","family":"Aliprandi","sequence":"additional","affiliation":[{"name":"Dipartimento Di Scienze Chimiche Universit\u00e0 Degli Studi di Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9228-6082","authenticated-orcid":false,"given":"Giulia","family":"Veronesi","sequence":"additional","affiliation":[{"name":"CNRS, CEA, IRIG, Laboratoire de Chimie et Biologie des M\u00e9taux Universit\u00e9 Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-1335","authenticated-orcid":false,"given":"Giorgio","family":"Facchetti","sequence":"additional","affiliation":[{"name":"Dipartimento Di Scienze Farmaceutiche Universit\u00e0 Degli Studi di Milano  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6210-0264","authenticated-orcid":false,"given":"Isabella","family":"Rimoldi","sequence":"additional","affiliation":[{"name":"Dipartimento Di Scienze Farmaceutiche Universit\u00e0 Degli Studi di Milano  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9673-1064","authenticated-orcid":false,"given":"Angela","family":"Tino","sequence":"additional","affiliation":[{"name":"Istituto Di Scienze Applicate e Sistemi Intelligenti \u201cE.Caianiello\u201d National Research Council  Pozzuoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1447-7611","authenticated-orcid":false,"given":"Claudia","family":"Tortiglione","sequence":"additional","affiliation":[{"name":"Istituto Di Scienze Applicate e Sistemi Intelligenti \u201cE.Caianiello\u201d National Research Council  Pozzuoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2152-6517","authenticated-orcid":false,"given":"Luisa","family":"De Cola","sequence":"additional","affiliation":[{"name":"Dipartimento Di Scienze Farmaceutiche Universit\u00e0 Degli Studi di Milano  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070821"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00884"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010024\u201000640\u2010z"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010022\u201000373\u2010x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312662"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00089"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00516"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00308"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-95-1188-4_4"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.201800118"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010020\u20100215\u2010y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4474"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2020.06.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr030071r"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422\u2010021\u201000491\u2010z"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010023\u201001199\u2010w"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202421713"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2020.101036"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202500144"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b02014"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr5004198"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/b105159h"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/b904665h"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010023\u201000589\u20103"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anbr.202200148"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007698"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b15433"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn305747e"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202405832"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.9b00373"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.08.025"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101022"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2383"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202013474"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1246\/cl.150592"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cs60453e"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201802743"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b07710"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00577724"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav9314"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12091265"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01670"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1378649"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14812"},{"key":"e_1_2_9_46_1","volume-title":"Advances in Aquatic Invertebrate Stem Cell Research","author":"Ballarin L.","year":"2022"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030660"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010020\u201003208\u20107"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2012.08.002"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2022.01.001"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.50"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2008.07.001"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2009.03.006"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4cc01045k"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0717\u201097072010000100016"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm2010902"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202410118"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.222"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2017.05.002"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00081"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202405400"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202405282"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.7957354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.7957354","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.7957354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:58:42Z","timestamp":1787720322000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.7957354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":61,"alternative-id":["10.1002\/anie.7957354"],"URL":"https:\/\/doi.org\/10.1002\/anie.7957354","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]},"assertion":[{"value":"2026-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7957354"}}