{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:58:00Z","timestamp":1791226680774,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"41","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Electrochemical reduction reaction of carbon monoxide (CORR) has been extensively studied due to its high selectivity for producing multi\u2010carbon (C\n                    <jats:sub>2+<\/jats:sub>\n                    ) products. However, the selective production of alcohol\u2010an highly valuable class of chemical feedstock\u2010remains unsatisfactory, hindered by poor selectivity and low energy efficiency. Here, we report that low coordination (unsaturated) Cu sites generated through the reduction of Cu\n                    <jats:sub>2<\/jats:sub>\n                    O catalysts with ammonia increases the binding energy of CO and enable the pre\u2010protonation of *CO to *CHO, as opposed to CO\u2013CO coupling. This modification enables a shift from symmetric *CO\u2010*CO post\u2010protonation coupling to asymmetric *CO\u2010*CHO coupling, thereby promoting alcohol formation. The Faradaic efficiency for alcohol production reaches up to 64.5% (51.5% for ethanol and 13% for 1\u2010propanol) at 500\u00a0mA cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    , with a full\u2010cell alcohol energy efficiency of \u223c27.1% and over 120\u00a0h of stable operation in a membrane electrode assembly. In situ spectroscopy and theory calculation reveal the preferential formation of key intermediates (*CHO, *COCHO, and *OC\n                    <jats:sub>2<\/jats:sub>\n                    H\n                    <jats:sub>5<\/jats:sub>\n                    ) along the alcohol production pathway on the unsaturated Cu sites. This strategy of tuning intermediate pre\u2010protonation offers a promising direction for catalyst design aimed at converting carbon emissions into value\u2010added products.\n                  <\/jats:p>","DOI":"10.1002\/anie.7989553","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T11:36:09Z","timestamp":1786016169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unsaturated Copper Sites for Selective Electroreduction of CO to Alcohol"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5470-7525","authenticated-orcid":false,"given":"Jia","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Chemistry National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0289-0185","authenticated-orcid":false,"given":"Ouwen","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Chemistry National University of Singapore  Singapore"},{"name":"Current address: Illinois Advanced Research Center at Singapore Illinois ARCS, 1 CREATE Way Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changgeng","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute For Theoretical Physics and Bremen Center For Computational Materials Science University of Bremen  Bremen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengtian","family":"Jin","sequence":"additional","affiliation":[{"name":"Clean energy research platform King Abdullah University of Science and Technology (KAUST)  Thuwal Saudi 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