{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:06:55Z","timestamp":1788930415122,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The synthesis of pyrroles, fundamental nitrogen\u2010heterocyclic scaffolds in pharmaceuticals and materials science, remains a synthetic challenge, typically requiring pre\u2010functionalized precursors and multi\u2010step protocols. Here, we report an efficient cascade synthesis of\n                    <jats:italic>N<\/jats:italic>\n                    \u2010substituted pyrroles directly from bio\u2010derived furans and nitroarenes, enabled by a synergistic bifunctional catalyst. The catalyst, featuring highly dispersed platinum (Pt) clusters anchored on a Br\u00f8nsted acid\u2010rich zeolite (HY), achieves near\u2010quantitative yields (up to 97%) under atmospheric H\n                    <jats:sub>2<\/jats:sub>\n                    pressure. Systematic characterization, including aberration\u2010corrected transmission electron microscopy and x\u2010ray absorption spectroscopy, reveals that the Pt clusters provide the necessary moderate hydrogenation activity, thereby selectively reducing nitroarenes to anilines while leaving the furan ring intact. In contrast, Pt nanoparticles, owing to their excessive hydrogenation activity, lead to undesired over\u2010hydrogenation of both the furan and benzene rings. The zeolite's Br\u00f8nsted acid sites subsequently facilitate a rapid ring\u2010opening\/condensation sequence, enabling an oxygen\u2010to\u2010nitrogen transmutation to form pyrroles. This atom\u2010economic strategy tolerates a broad range of functional groups (&gt;30 examples) and is further validated by the streamlined synthesis of a potent antimycobacterial drug candidate. Our findings demonstrate how modulating the electronic structure and ensemble configuration of noble metals at the atomic scale can unlock novel, sustainable transformation pathways for biomass\u2010derived platform chemicals.\n                  <\/jats:p>","DOI":"10.1002\/anie.8203203","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:15:54Z","timestamp":1788927354000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sustainable Access to\n                    <i>N<\/i>\n                    \u2010Heterocycles: One\u2010Pot Cascade Synthesis of Pyrroles From Bio\u2010Derived Furans"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9387-1195","authenticated-orcid":false,"given":"Haifeng","family":"Qi","sequence":"first","affiliation":[{"name":"Leibniz\u2010Institut F\u00fcr Katalyse  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7006-2273","authenticated-orcid":false,"given":"Germ\u00e1n","family":"L\u00f3pez Robledo","sequence":"additional","affiliation":[{"name":"Leibniz\u2010Institut F\u00fcr Katalyse  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianglin","family":"Duan","sequence":"additional","affiliation":[{"name":"Leibniz\u2010Institut F\u00fcr Katalyse  Rostock Germany"},{"name":"Interdisciplinary Research Center of Biology &amp; Catalysis School of Life Science and Technology Northwestern Polytechnical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0851-8248","authenticated-orcid":false,"given":"Yujing","family":"Ren","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Center of Biology &amp; Catalysis School of Life Science and Technology Northwestern Polytechnical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7044-8888","authenticated-orcid":false,"given":"Kathrin","family":"Junge","sequence":"additional","affiliation":[{"name":"Leibniz\u2010Institut F\u00fcr Katalyse  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5709-0965","authenticated-orcid":false,"given":"Matthias","family":"Beller","sequence":"additional","affiliation":[{"name":"Leibniz\u2010Institut F\u00fcr Katalyse  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.201301095"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7GC02299A"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00842"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00248"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201610964"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929\u2010018\u20100202\u20106"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/32.9.1955"},{"key":"e_1_2_8_9_1","unstructured":"R.Davey \u201cWhat Chemical Elements Are Found in the Human Body? \u201d in News Medical Life Sciences 2025 https:\/\/www.news\u2010medical.net\/documents\/final\/103\u201021054\u2010202306190302\u2010What\u2010Chemical\u2010Elements\u2010are\u2010Found\u2010in\u2010the\u2010Human\u2010Body.pdf."},{"key":"e_1_2_8_10_1","unstructured":"M. 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