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In this context, we report the synthesis and characterization of water\u2010dispersible ruthenium nanoparticles stabilized by the commercially available phosphine ligand sSPhos, and their application as catalysts for carbonyl reduction reactions under low\u2010pressure deuterium and tritium atmospheres. Using this nanocatalyst, a broad range of functionalized deuterated alcohols was successfully obtained in high isotopic enrichment from diverse aldehyde precursors, including a large cyclic peptide derivative (acetyl\u2010cyclosporin A). Mechanistic investigations revealed that in some cases, deuterium incorporation proceeds through both hydrogen isotope exchange on the aldehyde starting material and the reductive deuteration pathway. 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