{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:55:49Z","timestamp":1791294949692,"version":"4.1.0"},"reference-count":73,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/W015706\/1"],"award-info":[{"award-number":["EP\/W015706\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R01566X\/1"],"award-info":[{"award-number":["MR\/R01566X\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_PC_19035"],"award-info":[{"award-number":["MC_PC_19035"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Photodynamic therapy (PDT) is a promising strategy to eradicate residual glioma cells in brain cancer patients; however, current photosensitizers (PS) show limitations on selective accumulation and controlled activation in glioma cells. In this work, we present the design, synthesis, and characterization of activatable PSs for selective PDT of glioma cells in mouse and human brain tissues. First, we designed and characterized a broad collection of photosensitive metabolite conjugates, from which we prepared\n                    <jats:bold>Gal\u2010SeNBD\u2010oleamide<\/jats:bold>\n                    as a \u03b2\u2010galactosidase\u2010responsive PS with efficient uptake in patient\u2010derived glioma cells and selectivity over immune cells. Furthermore, we optimized a whole\u2010tissue illumination strategy using\n                    <jats:bold>Gal\u2010SeNBD\u2010oleamide<\/jats:bold>\n                    in mouse brain slices, which led to efficient ablation of cancer cells with minimal damage to surrounding regions. Finally, the proof\u2010of\u2010concept application of\n                    <jats:bold>Gal\u2010SeNBD\u2010oleamide<\/jats:bold>\n                    directly in tissues from brain cancer patients supports its translational potential for PDT of glioblastoma.\n                  <\/jats:p>","DOI":"10.1002\/anie.8453410","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:58:19Z","timestamp":1790812699000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sequential Design of Activatable Photosensitizers for Ablation of Glioma Cells in Brain Cancer Tissues"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5323-3500","authenticated-orcid":false,"given":"Utsa","family":"Karmakar","sequence":"first","affiliation":[{"name":"Centre for Inflammation Research The University of Edinburgh  Edinburgh UK"},{"name":"IRR Chemistry Hub, Institute for Regeneration and Repair The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Cheng","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research The University of Edinburgh  Edinburgh UK"},{"name":"IRR Chemistry Hub, Institute for Regeneration and Repair The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D. M.","family":"Green","sequence":"additional","affiliation":[{"name":"Institute of Photonics and Quantum Sciences Heriot\u2010Watt University  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Benson","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research The University of Edinburgh  Edinburgh UK"},{"name":"IRR Chemistry Hub, Institute for Regeneration and Repair The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Nestoros","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research The University of Edinburgh  Edinburgh UK"},{"name":"IRR Chemistry Hub, Institute for Regeneration and Repair The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2473-6015","authenticated-orcid":false,"given":"Clarissa","family":"Lim","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research The University of Edinburgh  Edinburgh UK"},{"name":"IRR Chemistry Hub, Institute for Regeneration and Repair The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Cholewa\u2010Waclaw","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"de Moliner","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research The University of Edinburgh  Edinburgh UK"},{"name":"IRR Chemistry Hub, Institute for Regeneration and Repair The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Lusarreta","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research The University of Edinburgh  Edinburgh UK"},{"name":"IRR Chemistry Hub, Institute for Regeneration and Repair The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0289-3669","authenticated-orcid":false,"given":"Deborah","family":"Seah","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research The University of Edinburgh  Edinburgh UK"},{"name":"IRR Chemistry Hub, Institute for Regeneration and Repair The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alsadeg","family":"Bilal","sequence":"additional","affiliation":[{"name":"Center for Clinical Brain Sciences Institute for Neuroscience and Cardiovascular Research The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neza","family":"Alfazema","sequence":"additional","affiliation":[{"name":"Centre For Regenerative Medicine Institute for Regeneration and Repair The University of Edinburgh  Edinburgh UK"},{"name":"Cancer Research UK Scotland Centre The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5522-8422","authenticated-orcid":false,"given":"Thibaud","family":"Aymoz\u2010Bressot","sequence":"additional","affiliation":[{"name":"Centre For Regenerative Medicine Institute for Regeneration and Repair The University of Edinburgh  Edinburgh UK"},{"name":"Cancer Research UK Scotland Centre The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Morrison","sequence":"additional","affiliation":[{"name":"Centre For Regenerative Medicine Institute for Regeneration and Repair The University of Edinburgh  Edinburgh UK"},{"name":"Cancer Research UK Scotland Centre The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8460-0884","authenticated-orcid":false,"given":"Sonja","family":"Vermeren","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Pollard","sequence":"additional","affiliation":[{"name":"Centre For Regenerative Medicine Institute for Regeneration and Repair The University of Edinburgh  Edinburgh UK"},{"name":"Cancer Research UK Scotland Centre The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7347-830X","authenticated-orcid":false,"given":"Paul M.","family":"Brennan","sequence":"additional","affiliation":[{"name":"Center for Clinical Brain Sciences Institute for Neuroscience and Cardiovascular Research The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7432-0312","authenticated-orcid":false,"given":"Michael G.","family":"Tanner","sequence":"additional","affiliation":[{"name":"Institute of Photonics and Quantum Sciences Heriot\u2010Watt University  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5392-9740","authenticated-orcid":false,"given":"Marc","family":"Vendrell","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research The University of Edinburgh  Edinburgh UK"},{"name":"IRR Chemistry Hub, Institute for Regeneration and Repair The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0708126"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noac202"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(09)70025\u20107"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.17"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.6.5.719"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1308573"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043330"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baz085"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1188\/16.CJON.S1.2-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1991.474"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202404107"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2017.02.011"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2011.10.007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202204788"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2010.02.020"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1071"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15133427"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122808"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr900236h"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc32292g"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cplu.202000203"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2014.03.002"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/co200136b"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215324"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202423348"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00173B"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CC00683B"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2OB01937J"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202404587"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201058239\u20105"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202300199"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.2c00202"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202307288"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c18237"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1562\/2006\u201005\u201003\u2010IR\u2010891"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1ob05519d"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.568337"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02765099"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13219"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201900465"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201022578\u20102"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201802877"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201051872\u2010y"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.12.001"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.02.004"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010020\u201001114\u20101"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8101203"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101453"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55985-z"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS01079D"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202509416"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/p29770000178"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.06.003"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC02069B"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21848"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.2c00484"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202216142"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/qsar.200420013"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm060947x"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742\u20104658.2010.07919.x"},{"key":"e_1_2_8_62_1","first-page":"6027","article-title":"Cathepsin B Expression and Localization in Glioma Progression and Invasion","volume":"54","author":"Rempel S. A.","year":"1994","journal-title":"Cancer Research"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2000.11740701"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3839"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201029691\u2010w"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109258(19)77815\u20106"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00070"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00928E"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264\u2010023\u201001077\u2010y"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010020\u201000789\u2010y"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.04.055"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26062726"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s101030200027"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.03.023"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.8453410","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.8453410","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.8453410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:08:11Z","timestamp":1791292091000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.8453410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":73,"alternative-id":["10.1002\/anie.8453410"],"URL":"https:\/\/doi.org\/10.1002\/anie.8453410","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2026-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8453410"}}