{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:03:07Z","timestamp":1789844587419,"version":"4.0.1"},"reference-count":71,"publisher":"Wiley","issue":"34","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,8,17]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Most design strategies in asymmetric transition metal catalysis invoke repulsive interactions between ligand and substrate. Yet those that incorporate attractive interactions can offer advantages, such as rate acceleration and greater generality, due to the fundamentally different mode of operation. Here we deploy electrostatically\u2010directed Pd catalysis using the chiral sulfonated ligand sSPhos to realize an asymmetric aminoarylation of\n                    <jats:italic>ortho<\/jats:italic>\n                    \u2010allyl anilines under mild conditions. A wide variety of substituted aryl bromides and anilines provide access to 2\u2010benzylindolines with high enantioselectivity. Our study uncovers trends relating the electronics of both coupling partners to\n                    <jats:italic>ee<\/jats:italic>\n                    . These trends allowed tuning of the sulfonamide protecting group to enable good results across a broader range of substrates.\n                  <\/jats:p>","DOI":"10.1002\/anie.8602143","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:39:46Z","timestamp":1782135586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Enantioselective Alkene Aminoarylation to Form Chiral Indolines via Electrostatically\u2010Directed Palladium Catalysis"],"prefix":"10.1002","volume":"65","author":[{"given":"Max","family":"Kadarauch","sequence":"first","affiliation":[{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul T.","family":"Jirsch","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Erik","family":"Diepers","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamzah","family":"Sharif","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7383-5469","authenticated-orcid":false,"given":"Robert J.","family":"Phipps","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.153.3739.954"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/md13084814"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103436"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867327666201102114923"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/open.202200235"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201000323"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol049317k"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol1019234"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja103668q"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201105341"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja4082827"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja502020b"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b06295"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201607890"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8QO00710A"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201913656"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c00298"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0657859"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol9002543"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2sc20111a"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja406004q"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201403985"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201510692"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201700977"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201022658\u20103"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201301618"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b08834"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.3c00516"},{"key":"e_1_2_8_30_1","article-title":"Copper\u2010catalyzed generation of nitrogen\u2010centered radicals and reactions thereof","author":"Chemler S. 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The methoxy substituent in4cis positionedorthowith respect to the allyl substituent. We judged that this would exert a greater steric effect on the reaction so chose only to include4bin the Hammett plot."},{"key":"e_1_2_8_66_1","unstructured":"We elected to include the 3 5\u2010CF3\u2010substituted sulfonamide (5e) in this Hammett plot to analyze the broadest possible range of protecting groups."},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja973468j"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo801631v"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja054754v"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2SC20903A"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5c00121"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.4c00849"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.8602143","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.8602143","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.8602143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:25:16Z","timestamp":1789842316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.8602143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":71,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2026,8,17]]}},"alternative-id":["10.1002\/anie.8602143"],"URL":"https:\/\/doi.org\/10.1002\/anie.8602143","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"assertion":[{"value":"2026-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8602143"}}