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In this study, we introduce poly(acrylic acid) brushes grafted onto conjugated microporous polymers (CMPs) to anchor Rh* complexes (\n                    <jats:italic>c<\/jats:italic>\n                    PTT\u2010P\u2010Rh*). The negatively charged brushes ensure excellent dispersibility and prevent Rh* leaching via electrostatic interactions. They also serve as a conductive pathway for internal electron transfer from the photocatalyst to the anchored Rh*, which is more efficient than intermolecular transfer. Moreover, the brushes physically shield photogenerated holes, protecting the enzyme from both free Rh* and hole\u2010induced damage. Using a low\u2010power 10 W 460\u00a0nm LED light, this system achieves 87.7% NADH regeneration (with exclusive 1,4\u2010NADH production) within 15 min with a turnover frequency (TOF) of 93.3 h\n                    <jats:sup>\u22121<\/jats:sup>\n                    , comparable to the highest reported values in the literature. Notably, the enzyme retains 76.8% activity after photocatalysis, and circular dichroism confirms no damage to protein secondary structure. The catalyst maintains 61.1% activity after seven cycles. This brush design uniquely integrates immobilization, electron transfer, and protection for efficient photobiocatalysis.\n                  <\/jats:p>","DOI":"10.1002\/anie.8631704","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:23:03Z","timestamp":1787656983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Conjugated Microporous Polymers Bearing Poly(Acrylic Acid) Brushes: Site\u2010Specific Rhodium Immobilization for Efficient and Enzyme\u2010Compatible Photocatalytic NADH Regeneration"],"prefix":"10.1002","volume":"65","author":[{"given":"Zi Yang","family":"Dong","sequence":"first","affiliation":[{"name":"Key Laboratory of Biomedical Polymers of Ministry of Education College of Chemistry and Molecular Sciences Wuhan University  Wuhan Hubei P. R. China"},{"name":"Hubei Key Lab on Organic and Polymeric Opto\u2010Electronic Materials College of Chemistry and Molecular Sciences Wuhan University  Wuhan Hubei P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin Xuan","family":"Fang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Polymers of Ministry of Education College of Chemistry and Molecular Sciences Wuhan University  Wuhan Hubei P. R. China"},{"name":"Hubei Key Lab on Organic and Polymeric Opto\u2010Electronic Materials College of Chemistry and Molecular Sciences Wuhan University  Wuhan Hubei P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong Ying","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Polymers of Ministry of Education College of Chemistry and Molecular Sciences Wuhan University  Wuhan Hubei P. R. 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