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Here, a small series of osmium(II) polypyridyl complexes was synthesized, and their biological activity in the dark and upon light irradiation against various cancer cell lines was studied. The compound\n                    <jats:bold>Os2<\/jats:bold>\n                    (bearing two 4,7\u2010diphenyl\u20101,10\u2010phenanthrolines and one substituted bipyridine ligand) was discovered to be the most effective photosensitizer (PS) for photodynamic therapy (PDT) of this series through the photogeneration of\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and \u2022OH. In addition,\n                    <jats:bold>Os2<\/jats:bold>\n                    was found to exhibit promising toxicity upon deep\u2010red irradiation under both normoxia and hypoxia. These observations indicate that this PS is working through a mixture of Type\u2010I and Type\u2010II mechanisms. More interestingly, upon 740\u00a0nm irradiation,\n                    <jats:bold>Os2<\/jats:bold>\n                    can stimulate a strong ICD response on CT26 and MCA205 cells both in vitro and in vivo. A comprehensive immune analysis showed that mice vaccinated with\n                    <jats:bold>Os2<\/jats:bold>\n                    \u2010treated CT26\u2010luc cells boosted the systemic specific adaptive immune responses, including the activation of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells and reprogramming of macrophages, leading to effective inhibition of tumor growth.\n                    <jats:bold>Os2<\/jats:bold>\n                    is, to the best of our knowledge, the first photoactive osmium\u2010based complex inducing ICD.\n                  <\/jats:p>","DOI":"10.1002\/anie.8677989","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:41:16Z","timestamp":1778560876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Deep\u2010Red\u2010Absorbing Osmium(II) Complex as a Photosensitizer for Photodynamic Therapy Inducing Immunogenic Cell Death"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7572-5685","authenticated-orcid":false,"given":"Yiyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences Laboratory For Inorganic Chemical Biology  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1069-2138","authenticated-orcid":false,"given":"Pierre","family":"Mesdom","sequence":"additional","affiliation":[{"name":"Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences Laboratory For Inorganic Chemical Biology  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7253-6934","authenticated-orcid":false,"given":"Eduardo","family":"Izquierdo\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences Laboratory For Inorganic Chemical Biology  Paris France"},{"name":"Departament de Qu\u00edmica Inorg\u00e0nica i Org\u00e0nica, Secci\u00f3 de Qu\u00edmica Org\u00e0nica Universitat De Barcelona (UB) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0144-694X","authenticated-orcid":false,"given":"Jo\u00e3o P. 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