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The structure and function of these assemblies are decisively influenced by the design of their molecular components. In this work, we present a modular synthetic strategy for six novel bio\u2010functional surfactants with a sulfonate headgroup (termed\n                    <jats:italic>SupraVir<\/jats:italic>\n                    surfactants). These amphiphilic molecules were designed for strong interactions with viral envelope proteins, virus inhibition, and to co\u2010assemble water\u2010soluble benzene\u20101,3,5\u2010tricarboxamide derivatives (BTAs) to generate surfactant\u2010grafted supramolecular polymers. Systematic spectroscopic and microscopic studies showed that the morphology of the co\u2010assemblies strongly depends on the surfactant\u2010BTA ratio. At surfactant ratios higher than 1, the native BTA nanofibers were disrupted, resulting in micellar architectures. In the test with herpes simplex virus (HSV\u20101), fibrous supramolecular polymers show significantly lower half\u2010maximal inhibitory concentrations (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) compared to the corresponding micellar aggregates of the pure surfactants. Interestingly, the co\u2010assemblies exhibited lower cytotoxicity than the functional surfactants alone, probably due to their structured incorporation into the polymeric scaffold. The dynamics of the co\u2010assemblies, probed by hydrogen\u2010deuterium exchange mass spectrometry (HDX\u2010MS), showed correlations to the effectiveness. These results demonstrate a new co\u2010assembly strategy of functional positioning antiviral surfactants in supramolecular scaffolds for the development of multivalent antiviral materials.\n                  <\/jats:p>","DOI":"10.1002\/anie.8702628","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T18:04:25Z","timestamp":1785089065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Supramolecular Polymer\u2010Surfactant Co\u2010Assemblies for Multivalent HSV\u20101 Inhibition"],"prefix":"10.1002","volume":"65","author":[{"given":"Christian","family":"Zoister","sequence":"first","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"},{"name":"Institute for Complex Molecular Systems, Laboratory of Macromolecular and Organic Chemistry Eindhoven University of Technology  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Schade","sequence":"additional","affiliation":[{"name":"Forschungszentrum f\u00fcr Elektronenmikroskopie, Core\u2010Facility BioSupraMol, Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Sittinger","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5403-3647","authenticated-orcid":false,"given":"Xianwen","family":"Lou","sequence":"additional","affiliation":[{"name":"Institute for Complex Molecular Systems, Laboratory of Macromolecular and Organic Chemistry Eindhoven University of Technology  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmee","family":"de Korver","sequence":"additional","affiliation":[{"name":"Institute for Complex Molecular Systems, Laboratory of Macromolecular and Organic Chemistry Eindhoven University of Technology  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freek V.","family":"de Graaf","sequence":"additional","affiliation":[{"name":"Institute for Complex Molecular Systems, Laboratory of Macromolecular and Organic Chemistry Eindhoven University of Technology  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranen","family":"Etouki","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanxiong","family":"Nie","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Licha","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Forschungszentrum f\u00fcr Elektronenmikroskopie, Core\u2010Facility BioSupraMol, Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8398-9947","authenticated-orcid":false,"given":"Abhishek Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"},{"name":"School of Biosciences Chanakya University  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4126-7492","authenticated-orcid":false,"given":"E. 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