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In this work, a dynamic chemical reconstruction strategy has been developed for PAH treatment through the in situ synthesis of antioxidant nanocatalyst MoO\n                    <jats:italic>\n                      <jats:sub>y<\/jats:sub>\n                    <\/jats:italic>\n                    and selenium oxyanions from a molybdenum selenide nanosystem in response to the oxidative microenvironment of PAH. MoO\n                    <jats:italic>\n                      <jats:sub>y<\/jats:sub>\n                    <\/jats:italic>\n                    nanoparticles catalyze the exogenous antioxidation reactions to scavenge ROS efficiently, while the soluble selenium oxyanions upregulate the expression of selenoproteins to reinforce the endogenous antioxidant defense system. These two processes cooperatively alleviate oxidative stress of pulmonary artery smooth muscle cells (PASMCs), thus suppressing their malignant proliferation\/migration and finally mitigating pulmonary arterial remodeling for PAH treatment. This work presents a dynamic chemical reconstruction strategy for in situ synthesis of exogenous and endogenous antioxidants, offering a dual\u2010axis antioxidation approach for the treatment of multiple redox imbalance\u2010associated diseases.\n                  <\/jats:p>","DOI":"10.1002\/anie.8724742","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:39:07Z","timestamp":1790696347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In\u2010Situ Dynamic Chemical Reconstruction Synthesis of Dual\u2010Antioxidants for Pulmonary Arterial Hypertension Treatment"],"prefix":"10.1002","author":[{"given":"Di","family":"Jiang","sequence":"first","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai People's Republic of China"},{"name":"Center of Materials Science and Optoelectronics 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