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The S\u2013S(O) motif, also present in biological systems, can be reduced to form disulfide bridges (RSSR\u2019), suggesting potential astrobiological relevance. Here, we report the first formation of sulfinothioic acid in astrophysically relevant sulfur dioxide (SO\n                    <jats:sub>2<\/jats:sub>\n                    )\u2013water (H\n                    <jats:sub>2<\/jats:sub>\n                    O) ices and its identification via isomer\u2010selective photoionization reflectron time\u2010of\u2010flight mass spectrometry combined with isotopic labeling. Irradiation of these ices at 5 K under ultrahigh vacuum with galactic cosmic\u2010ray proxies yields sulfinothioic acid. These results establish a missing link in interstellar sulfur chemistry and reveal a previously unrecognized class of astrochemically accessible sulfur oxyacids formed via radical\u2010mediated, non\u2010equilibrium processes driven by energetic particles in cold interstellar environments.\n                  <\/jats:p>","DOI":"10.1002\/anie.8731327","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:15:22Z","timestamp":1783678522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interstellar Ice Chemistry Yields Elusive Sulfinothioic Acid (HS(O)SH)"],"prefix":"10.1002","volume":"65","author":[{"given":"Mason","family":"McAnally","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Hawai\u02bbi at M\u0101noa  Honolulu HI USA"},{"name":"W. M. 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Keck Laboratory in Astrochemistry University of Hawai\u02bbi at M\u0101noa  Honolulu HI USA"},{"name":"Present Address: State Key Laboratory of Molecular Reaction Dynamics and Dalian Coherent Light Source Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Hawai\u02bbi at M\u0101noa  Honolulu HI USA"},{"name":"W. M. 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