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Despite notable advances in manufacturing, stabilization and modification, its short half\u2010life remains a major limitation. Circular RNA bears potential to solve this issue, as degradation of mRNA proceeds primarily from the 5\u2032 and 3\u2032 ends. However, circular RNAs normally lack a 5\u2032 cap and are less efficiently translated. We present a strategy to circularize mRNA covalently via click chemistry by modifying the 5\u2032 cap and the 3\u2032 poly(A) tail with bioorthogonal functional groups. The resulting Cyclic Click Cap\u2010containing mRNA (CyCliCap\u2010mRNA) is translationally muted by a photocleavable protecting group. Upon irradiation by light, the photocleavable protecting group is removed and the respective linear Cap0\u2010mRNA released. We show that CyCliCap\u2010mRNA can be activated for efficient translation at late timepoints (24\u201048 h post transfection) in HeLa cells, which is not possible with the respective linear mRNA. 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