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However, its broader application is limited by insufficient light penetration, rapid catalyst deactivation under biological conditions, and insufficient catalytic pathways under hypoxia. Here, we develop a near\u2010infrared (NIR)\u2010activated photocatalytic platform based on a donor\u2013acceptor conjugated macrocyclic photocatalyst that enables coupled NADH oxidation and nitric oxide (NO) release. The photocatalyst self\u2010assembles into J\u2010aggregates within micellar nanostructures, enabling efficient photocatalytic NADH oxidation under 808\u00a0nm light irradiation. Simultaneous encapsulation of an\n                    <jats:italic>N<\/jats:italic>\n                    \u2010nitrosamine\u2010based NO donor offers an oxygen\u2010independent electron acceptor, sustaining the photocatalytic cycle under hypoxia and enabling controlled NO release. Mechanistically, photocatalytic NADH depletion suppresses electron flux through the mitochondrial respiratory chain, while NO further impairs mitochondrial respiration, synergistically aggravating mitochondrial dysfunction and amplifying PCT efficacy. Moreover, this bioenergetic collapse downregulates heat shock protein (HSP)\u2010mediated stress responses, thereby sensitizing tumor cells to mild photothermal therapy (mPTT) mediated by the same J\u2010aggregated photocatalyst. This NO\u2010amplified PCT\u2013mPTT strategy not only induces potent tumor ablation but also remodels the immunosuppressive tumor microenvironment, effectively inhibiting both primary and distant tumor growth in vivo.\n                  <\/jats:p>","DOI":"10.1002\/anie.8769084","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:44:44Z","timestamp":1785941084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["J\u2010Aggregated Macrocyclic Photocatalysts Enable Nitric Oxide (NO)\u2010Enhanced Near\u2010Infrared Photocatalytic Tumor Therapy"],"prefix":"10.1002","volume":"65","author":[{"given":"Haochuan","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui Province 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University of Science and Technology of China (USTC), Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqiu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui Province 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