{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:04:05Z","timestamp":1789531445800,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP250101401"],"award-info":[{"award-number":["DP250101401"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT220100479"],"award-info":[{"award-number":["FT220100479"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["CE230100017"],"award-info":[{"award-number":["CE230100017"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP250100576"],"award-info":[{"award-number":["DP250100576"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22506090"],"award-info":[{"award-number":["22506090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2026QA13"],"award-info":[{"award-number":["ZR2026QA13"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Developing single\u2010atom nanozymes with stereoconfigurations is a new paradigm for biomimetic construction of next\u2010generation natural enzyme alternatives and for achieving high enzyme\u2010like selectivity and activity. This work developed a high\u2010temperature pyrolysis tandem chemical vapor deposition technique to produce Cu SAzymes (Cu\u2010B\/N\u2010C) with axial B coordination as laccase mimics, with Cu\u2010B\n                    <jats:sub>axial<\/jats:sub>\n                    N\n                    <jats:sub>3<\/jats:sub>\n                    \u2010C as the core structure. Axial ligands modulate the d\u2010band center of Cu SAzymes to identify the equilibrium point between the energy barriers of reactant adsorption and product desorption. Transforming product desorption from an endothermic process to a spontaneously exothermic process promotes the regeneration of nanozymes after catalytic cycles. This results in Cu\u2010B\/N\u2010C exhibiting higher kinetic parameters and specific activity than natural laccase. Subsequently, a sensor array for high\u2010throughput detection of phenolic pollutants in seawater was constructed based on the time\u2010dependent changes in the laccase\u2010like catalytic kinetics of Cu SAzymes before and after modification. On this basis, a stepwise prediction model was further developed using machine\u2010learning artificial neural network algorithms to enhance the sensor array's detection accuracy for blind samples. Overall, this work provides new insights into the rational design of artificial enzymes from a stereochemical perspective.\n                  <\/jats:p>","DOI":"10.1002\/anie.8789610","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:14:46Z","timestamp":1789528486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Axial Boron Coordination Reconstructs Stereostructure of Cu Single\u2010Atom Nanozymes for Efficient Water\u2010Phase Chemical Sensing"],"prefix":"10.1002","author":[{"given":"Qijun","family":"Sun","sequence":"first","affiliation":[{"name":"Shandong Analysis and Test Center Qilu University of Technology (Shandong Academy of Sciences)  Jinan P.R. 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