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Processes that selectivity functionalize an\n                    <jats:italic>E<\/jats:italic>\n                    \u2010alkene in the presence of a\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010alkene remain elusive, however, they would be an attractive approach to access chiral molecules with a remaining group capable of stereospecific functionalization. Here, we report the\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010retentive enantioselective Rh\u2010catalyzed hydroarylation of electron\u2010poor\n                    <jats:italic>E,Z<\/jats:italic>\n                    \u2010dienes. The reaction gives targets in &gt;95% ee without alkene\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010to\u2010\n                    <jats:italic>E<\/jats:italic>\n                    isomerization. The product \u03b2\u2010aryl\u2010\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010\u03b3,\u03b4\u2010unsaturated carbonyl compounds can be readily transformed into polyfunctional products containing multiple adjacent stereocenters in high diastereomeric ratios (\u226590:10) via stereospecific alkene functionalizations. Mechanistic studies suggest that Rh\u2010enolate protonolysis is the turnover\u2010limiting step, and a selectivity model is developed based on reactivity and kinetic studies with\n                    <jats:italic>E,E<\/jats:italic>\n                    \u2010dienes and\n                    <jats:italic>E\/Z<\/jats:italic>\n                    \u2010alkenes. DFT studies were used to shed light on the nature of the substrate\u2010catalyst interactions which likely lead to the observed selectivity. These results may have wide spanning implications for developing new\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010retentive alkene addition reactions.\n                  <\/jats:p>","DOI":"10.1002\/anie.8809022","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:31:13Z","timestamp":1790425873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Z<\/i>\n                    \u2010Retentive Enantioselective Rh\u2010Catalyzed Hydroarylation of\n                    <i>E,Z<\/i>\n                    \u2010Dienes"],"prefix":"10.1002","volume":"65","author":[{"given":"Wesley","family":"McNutt","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hima","family":"Kozhummal","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5274-4348","authenticated-orcid":false,"given":"Abdullah","family":"Al\u2010Mashqbeh","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5384-9222","authenticated-orcid":false,"given":"Alex","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7760-6946","authenticated-orcid":false,"given":"Rylan J.","family":"Lundgren","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00162"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.0c00093"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.9b04480"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00383"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/cs200562n"},{"key":"e_1_2_8_7_1","first-page":"1","article-title":"Enantioselective, Rhodium\u2010Catalyzed 1, 4\u2010Addition of Organoboron Reagents to Electron\u2010Deficient Alkenes","volume":"93","author":"Burns A. 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