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Here we report a class of artificial transmembrane channels constructed from discrete covalent organic nanotubes that mediate the selective transmembrane transport of AA. X\u2010ray structural analysis and vesicle\u2010based fluorescence assays confirmed that these molecules adopt a rigid tubular architecture with a near\u2010nanometer pore size, enabling their insertion into lipid bilayers to form stable transmembrane channels that mediate efficient AA transport. Importantly, AA transport mediated by these molecules can initiate bioorthogonal reactions, thereby converting an external chemical stimulus into a fluorescent signal within a biomimetic system.<\/jats:p>","DOI":"10.1002\/anie.8870673","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:28:23Z","timestamp":1780590503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Artificial Transmembrane Channels for Selective Ascorbic Acid Transport and Bioorthogonal Signal Transduction"],"prefix":"10.1002","volume":"65","author":[{"given":"Linlin","family":"Shi","sequence":"first","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs Pingyuan Laboratory School of Pharmaceutical Sciences School of Chemistry and Chemical Engineering Henan Normal University  Xinxiang 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