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In this study, we report an oxygen\u2010tolerant photoinduced electron\/energy transfer reversible addition\u2013fragmentation chain transfer (PET\u2010RAFT) polymerization approach for the synthesis of degradable copolymers from cyclic dithiothreitol (cDTT) and a broad range of technologically relevant\n                    <jats:italic>N<\/jats:italic>\n                    \u2010vinyl monomers, as well as other less activated monomers. This method gives access to well\u2010defined copolymers with predictable molecular weights, low dispersities, and efficient cDTT incorporation. Degradable polymers were accessed using low cDTT feed ratios (2\u201310 mol%), enabling the preparation of materials with compositions dominated by the parent vinyl monomers while presenting multiple cleavable sites along the backbone. The incorporated cDTT generates disulfide, thioaminal, and vicinal diol functionalities, thereby enabling backbone degradation under reductive, acidic, and oxidative conditions. Despite the low cDTT content employed, which limits the extent of reductive cleavage, periodate\u2010mediated oxidation enabled efficient and rapid backbone degradation. This work expands the scope of cyclic disulfides as comonomers in rROP and provides a practical route to degradable vinyl materials based on widely used\n                    <jats:italic>N<\/jats:italic>\n                    \u2010vinyl species.\n                  <\/jats:p>","DOI":"10.1002\/anie.9026373","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:57:51Z","timestamp":1790258271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxygen\u2010Tolerant, Controlled Synthesis of Degradable and Water\u2010Soluble Poly(Vinyl Amide)s via Radical Ring\u2010Opening Copolymerization of Cyclic Dithiothreitol"],"prefix":"10.1002","author":[{"given":"Alessandro","family":"Magro","sequence":"first","affiliation":[{"name":"Department of Chemistry Carnegie Mellon University  Pittsburgh Pennsylvania USA"},{"name":"Laboratory For Macromolecular and Organic Chemistry (MOC) Department of 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