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We here introduce ligand\n                    <jats:bold>\n                      L\n                      <jats:sup>A<\/jats:sup>\n                    <\/jats:bold>\n                    , based on a flexible and reactive 1,2\u2010dicarbonyl benzil\u2010based backbone, able to adopt several conformations. A range of homo\u2010 and heteroleptic Pd(II) assemblies is formed with different nuclearities and topologies, connected through distinct transformation pathways. In homoleptic systems, folded and open conformations of\n                    <jats:bold>\n                      L\n                      <jats:sup>A<\/jats:sup>\n                    <\/jats:bold>\n                    afford the mononuclear complex Pd\n                    <jats:bold>\n                      L\n                      <jats:sup>A<\/jats:sup>\n                    <\/jats:bold>\n                    <jats:sub>2<\/jats:sub>\n                    and the lantern\u2010shaped cage Pd\n                    <jats:sub>2<\/jats:sub>\n                    <jats:bold>\n                      L\n                      <jats:sup>A<\/jats:sup>\n                    <\/jats:bold>\n                    <jats:sub>4<\/jats:sub>\n                    . Incorporation of secondary ligands\n                    <jats:bold>\n                      L\n                      <jats:sup>C<\/jats:sup>\n                    <\/jats:bold>\n                    or\n                    <jats:bold>\n                      L\n                      <jats:sup>D<\/jats:sup>\n                    <\/jats:bold>\n                    induces more expanded\n                    <jats:bold>\n                      L\n                      <jats:sup>A<\/jats:sup>\n                    <\/jats:bold>\n                    conformations, yielding\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010Pd\n                    <jats:sub>2<\/jats:sub>\n                    <jats:bold>\n                      L\n                      <jats:sup>A<\/jats:sup>\n                    <\/jats:bold>\n                    <jats:sub>2<\/jats:sub>\n                    <jats:bold>\n                      L\n                      <jats:sup>C<\/jats:sup>\n                    <\/jats:bold>\n                    <jats:sub>2<\/jats:sub>\n                    or a rare isosceles triangular Pd\n                    <jats:sub>3<\/jats:sub>\n                    <jats:bold>\n                      L\n                      <jats:sup>A<\/jats:sup>\n                    <\/jats:bold>\n                    <jats:sub>2<\/jats:sub>\n                    <jats:bold>\n                      L\n                      <jats:sup>D<\/jats:sup>\n                    <\/jats:bold>\n                    <jats:sub>4<\/jats:sub>\n                    ring. These heteroleptic architectures can be interconverted, and both can undergo guest\u2010induced retro\u2010cage\u2010to\u2010cage transformation to regenerate homoleptic species. Furthermore,\n                    <jats:bold>\n                      L\n                      <jats:sup>A<\/jats:sup>\n                    <\/jats:bold>\n                    can also be conformationally locked through condensation of its benzil backbone with 1,2\u2010phenylenediamine, producing the rigid quinoxaline ligand\n                    <jats:bold>\n                      L\n                      <jats:sup>B<\/jats:sup>\n                    <\/jats:bold>\n                    . This transformation can occur in a post\u2010assembly fashion, converting both homoleptic and heteroleptic\n                    <jats:bold>\n                      L\n                      <jats:sup>A<\/jats:sup>\n                    <\/jats:bold>\n                    \u2010based structures into the Pd\n                    <jats:bold>\n                      L\n                      <jats:sup>B<\/jats:sup>\n                    <\/jats:bold>\n                    <jats:sub>2<\/jats:sub>\n                    complex. The conformation and accessibility of\n                    <jats:bold>\n                      L\n                      <jats:sup>A<\/jats:sup>\n                    <\/jats:bold>\n                    reactive sites within the architectures, as well as the nature of the encapsulated guest, strongly influence assembly stability and reactivity in this condensation, reminiscent of how nature controls functional group reactivity through effects of nanoscopic confinement, conformational restriction, and allosteric regulation.\n                  <\/jats:p>","DOI":"10.1002\/anie.9050553","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:29:39Z","timestamp":1783596579000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Multi\u2010Stimuli Transformational Network of Benzil\u2010Based Pd(II) Assemblies"],"prefix":"10.1002","volume":"65","author":[{"given":"Zhiwei","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Biology TU Dortmund University  Dortmund Germany"},{"name":"School of Chemistry and Chemical Engineering Nanjing University of Science and Technology  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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