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Under mild conditions (130\u00b0C, 20\u00a0bar, H\n                    <jats:sub>2<\/jats:sub>\n                    \/CO\n                    <jats:sub>2<\/jats:sub>\n                    :\u00a03), MIL\u201053\u2010Co(OH) achieves 92% CO\n                    <jats:sub>2<\/jats:sub>\n                    conversion with an ethanol productivity of 10\u00a0133\u00a0\u00b5mol g\n                    <jats:sub>cat<\/jats:sub>\n                    <jats:sup>\u22121<\/jats:sup>\n                    h\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 93% selectivity. Comparisons with the rigid MIL\u201068(Al) and breathing\u2010suppressed variants of MIL\u201053 MOFs revealed that the lattice flexibility of MIL\u201053\u2010Co(OH) enhances ethanol productivity by at least 3.5\u2010fold while suppressing the formation of CH\n                    <jats:sub>3<\/jats:sub>\n                    OH. Experimental, structural and computational analysis suggest that the reversible narrow\u2010pore (\n                    <jats:italic>np<\/jats:italic>\n                    )\u2194large\u2010pore (\n                    <jats:italic>lp<\/jats:italic>\n                    ) interconversion of MIL\u201053\u2010Co(OH) periodically optimizes the Al\n                    <jats:sub>2<\/jats:sub>\n                    [\n                    <jats:italic>\u03bc<\/jats:italic>\n                    <jats:sub>3<\/jats:sub>\n                    \u2010O\u2013Co(OH)] active\u2010site geometry at MOF's node, which synchronizes in situ generated CH\n                    <jats:sub>3<\/jats:sub>\n                    OH activation followed by CO insertion to promote C\u2012C coupling. During the\n                    <jats:italic>np<\/jats:italic>\n                    \u2192\n                    <jats:italic>lp<\/jats:italic>\n                    transition, the transient lattice expansion relaxes the Al\u2013[\n                    <jats:italic>\n                      \u03bc\n                      <jats:sub>3<\/jats:sub>\n                    <\/jats:italic>\n                    \u2010O\u2013Co(OH)]\u2013Al hinge, which reduces the activation barrier of\n                    <jats:italic>\u03c3<\/jats:italic>\n                    \u2010bond metathesis between the Co\u2013H bond and C\u2013O bond of CH\n                    <jats:sub>3<\/jats:sub>\n                    OH, a key step in the catalytic cycle. This strategy of leveraging conformational dynamics of MOFs for active\u2010site engineering opens new avenues in designing highly active earth\u2010abundant metal catalysts for challenging chemical transformations.\n                  <\/jats:p>","DOI":"10.1002\/anie.9130890","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T10:35:45Z","timestamp":1778495745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Leveraging Conformational Dynamics of MOFs to Overcome Conversion\u2010Selectivity Trade\u2010Off in CO\n                    <sub>2<\/sub>\n                    Hydrogenation to Ethanol"],"prefix":"10.1002","volume":"65","author":[{"given":"Manav","family":"Chauhan","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Delhi  New Delhi 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