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The method features broad substrate scopes, mild conditions, good tolerance of sensitive groups, low loading of nickel catalysts and ready scalability to synthesis in grams. The method was applied in concise preparation of ten medicinally relevant chiral benzylamines and azacycles. Kinetic profiling revealed that efficient Mn reduction contributed significantly to overall rates, and Lewis\u2010acidic titanium alkoxide assisted several reductive steps in the catalytic cycle. Density functional theory (DFT) calculations revealed a low\u2010barrier 1,2\u2010insertion of neutral complexes of aryl\u2010nickel(I) to imines. The cyclic linker of chiral bis(oxazoline) not only rigidifies the chelate ring formed on nickel, but also induces 99% ee or above during aryl transfer via Thorpe\u2010Ingold effect.<\/jats:p>","DOI":"10.1002\/anie.9277033","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:47:49Z","timestamp":1790822869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nickel\u2010Catalyzed Enantioselective Addition of Aromatic, Heteroaryl, and Alkenyl Halides to Aliphatic Aldimines"],"prefix":"10.1002","author":[{"given":"Xiuhua","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemical Oncogenomics Shenzhen Key Laboratory of Chemical Genomics School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School  Shenzhen 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