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Herein, we report a cyano\u2010terminated thioxanthene dioxide radical (\n                    <jats:bold>MR<\/jats:bold>\n                    ) as a robust building block for constructing complex di\u2010\/tetraradical architectures. The\n                    <jats:bold>MR<\/jats:bold>\n                    motif features a sulfone\u2010fused, quasi\u2010planar core that, synergized by electron\u2010withdrawing\n                    <jats:italic>para<\/jats:italic>\n                    \u2010cyano groups, provides significant thermodynamic stabilization to yield an exceptional ambient half\u2010life time (\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>1\/2<\/jats:sub>\n                    ) of 81 days. Leveraging this scaffold, we achieved the modular synthesis of an\n                    <jats:italic>m<\/jats:italic>\n                    \u2010phenylene\u2010bridged diradical (\n                    <jats:bold>DR<\/jats:bold>\n                    ) and a fully\u2010fused tetraradicaloid (\n                    <jats:bold>TR<\/jats:bold>\n                    ) via a high\u2010efficiency radical\u2010mediated oxidative cyclization protocol. While\n                    <jats:bold>DR<\/jats:bold>\n                    represents a rare air\u2010stable triplet\u2010ground\u2010state diradical (\u0394\n                    <jats:italic>E<\/jats:italic>\n                    <jats:sub>S\u2010T<\/jats:sub>\n                    \u00a0=\u00a00.13\u00a0kcal\/mol), the tetraradicaloid\n                    <jats:bold>TR<\/jats:bold>\n                    possesses a singlet ground state stabilized by global aromaticity across its \u03c0\u2010core, accompanied by an unconventional energy hierarchy featuring a quintet manifold as the lowest thermally accessible excited state. Notably,\n                    <jats:bold>TR<\/jats:bold>\n                    demonstrates excellent room\u2010temperature spin coherence, with spin\u2010lattice relaxation\/spin dephasing time (\n                    <jats:italic>\n                      T\n                      <jats:sub>1<\/jats:sub>\n                      \/T\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:italic>\n                    ) of 85.47\/1.17\u00a0\u00b5s, suggesting its good potential as robust spin qubits under ambient conditions. These results establish\n                    <jats:bold>MR<\/jats:bold>\n                    as a versatile radical motif for developing complex multi\u2010spin systems with emergent magnetic\/quantum information functionalities.\n                  <\/jats:p>","DOI":"10.1002\/anie.9341514","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:07:35Z","timestamp":1788152855000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Stable Thioxanthene Dioxide Radical Motif for Modular Access to High\u2010Spin Diradical and Fully\u2010Fused Tetraradicaloid Scaffold"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2790-8355","authenticated-orcid":false,"given":"Xujun","family":"He","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemo and Biosensing College of Chemistry and Chemical Engineering Hunan University  Changsha 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