{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:02:19Z","timestamp":1789837339298,"version":"4.0.1"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u2010JCJC\u20102020\u2010BO\u2010HAT"],"award-info":[{"award-number":["ANR\u2010JCJC\u20102020\u2010BO\u2010HAT"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Photo\u2010induced hydrogen atom transfer (HAT) catalysis has become a powerful platform for the direct and selective functionalization of ubiquitous C\u2500H bonds. Traditionally, the outcome of these transformations is dictated by the interplay between C\u2500H bond dissociation energies and polar effects, enabling predictable yet inherently substrate\u2010controlled selectivity. Recently, a fundamentally new strategy has emerged that relies on the catalytic and reversible modulation of substrate electronics to transiently enhance the reactivity of targeted C\u2500H bonds. Notably, catalytic full or partial deprotonation of oxygen\u2010 and nitrogen\u2010containing functional groups has proven remarkably effective in selectively activating adjacent C\u2500H bonds toward HAT, a phenomenon known as the anionic substituent effect. Rather than relying solely on the intrinsic properties of a substrate, this concept allows chemists to reprogram C\u2500H bond reactivity in situ, unlocking previously inaccessible levels of selectivity in the direct functionalization of abundant functional groups under mild photocatalytic conditions. In this minireview, we discuss the mechanistic principles underpinning catalytic anionic substituent effects (CASE), the diverse strategies developed to generate them, and their impact on photocatalytic HAT\u2010mediated C\u2013H functionalization. By highlighting recent advances and emerging opportunities, we illustrate how transient electronic activation is reshaping the design of selective C\u2013H functionalization reactions.<\/jats:p>","DOI":"10.1002\/anie.9361104","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:14:52Z","timestamp":1789834492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Catalytic Anionic Substituents Effects as Selectivity Mediators in Photocatalytic Hydrogen Atom Transfers"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2410-4969","authenticated-orcid":false,"given":"Ga\u00e9tan","family":"Archer","sequence":"first","affiliation":[{"name":"Universit\u00e9 Lyon 1, CNRS ICBMS  Villeurbanne France"},{"name":"Section of Organic Chemistry, Department of Inorganic and Organic Chemistry University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6032-4790","authenticated-orcid":false,"given":"Maurice","family":"M\u00e9debielle","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lyon 1, CNRS ICBMS  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2364-2535","authenticated-orcid":false,"given":"J\u00e9r\u00e9my","family":"Merad","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lyon 1, CNRS ICBMS  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1002\/ejoc.201601485","article-title":"Hydrogen Atom Transfer (HAT): A Versatile Strategy for Substrate Activation in Photocatalyzed Organic Synthesis","volume":"2017","author":"Capaldo L.","year":"2017","journal-title":"European Journal of Organic Chemistry"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1039\/D0GC01035A","article-title":"Photocatalytic Hydrogen Atom Transfer: The Philosopher's Stone for Late\u2010Stage Functionalization?","volume":"22","author":"Capaldo L.","year":"2020","journal-title":"Green Chemistry"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC04881J"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.checat.2021.04.008"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00263"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28166127"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC01118F"},{"key":"e_1_2_11_9_1","first-page":"1322","article-title":"Polarity Reversal Catalysis of Hydrogen Atom Abstraction Reactions","volume":"23","author":"Roberts B. 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