{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:16:09Z","timestamp":1789042569404,"version":"build-2803163510"},"reference-count":69,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571536"],"award-info":[{"award-number":["32571536"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271392"],"award-info":[{"award-number":["32271392"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22305098"],"award-info":[{"award-number":["22305098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Drug\u2010resistant bacterial infections and persistent oxidative stress severely impair nerve endings in burn wounds, presenting a formidable clinical challenge. Current treatment modalities generally fail to achieve simultaneous pathogenic eradication and neuro\u2010regeneration. Here, we design vanadium\u2010vacancy\u2010induced atomically polarized V\n                    <jats:sub>2<\/jats:sub>\n                    C\/VSe\n                    <jats:sub>2<\/jats:sub>\n                    heterojunctions (V\n                    <jats:sup>2<\/jats:sup>\n                    R\u2010HJs) to drive bioenergetic pathogen disruption and peripheral nerve regeneration. Vanadium\u2010vacancy\u2010boosted atomic\u2010level charge polarization enables V\n                    <jats:sup>2<\/jats:sup>\n                    R\u2010HJs to form potent Lewis acid\u2010base pairs to capture electrons and protons, exerting enhanced catalytic, multienzyme\u2010mimetic, and H\n                    <jats:sub>2<\/jats:sub>\n                    Se release activities. In infection, V\n                    <jats:sup>2<\/jats:sup>\n                    R\u2010HJs synergistically disrupt electron transport and collapse the proton motive force within the bacterial respiratory chain with sonocatalytic therapy, achieving 99.5% and 96.2% antibacterial efficiencies against\n                    <jats:italic>Cl\u2010MRSA<\/jats:italic>\n                    and\n                    <jats:italic>Cl\u2010DREC<\/jats:italic>\n                    , respectively. During healing, V\n                    <jats:sup>2<\/jats:sup>\n                    R\u2010HJs exhibit multienzyme\u2010like activities and release trace H\n                    <jats:sub>2<\/jats:sub>\n                    Se, alleviating oxidative injury and restoring the nerve regeneration microenvironment. Mechanistic investigations reveal that selenoprotein biosynthesis and PI3K\/Akt\/Nrf2 pathway activation accelerate neural cell growth. In\n                    <jats:italic>Cl\u2010MRSA<\/jats:italic>\n                    \u2010infected burn wounds, V\n                    <jats:sup>2<\/jats:sup>\n                    R\u2010HJs demonstrate superior therapeutic efficacy by reprogramming macrophages, boosting neovascularization, peripheral neural regeneration, and extracellular matrix remodeling, achieving 98.5% wound closure by Day 15. This atomic\u2010level charge\u2010polarized vacancy\u2010rich hetero\u2010architecture offers a paradigm for integrating pathogen bioenergetic disruption and targeted tissue restoration, opening a promising avenue for treating recalcitrant infection\u2010driven pathologies.\n                  <\/jats:p>","DOI":"10.1002\/anie.9441573","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:50:28Z","timestamp":1789041028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vanadium\u2010Vacancy\u2010Induced Atomically Polarized Heterojunctions for Synergistic Bioenergetic Pathogen Disruption and Peripheral Nerve Regeneration"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7390-8567","authenticated-orcid":false,"given":"Xiangnan","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Rong","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxing","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"He","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7421-3200","authenticated-orcid":false,"given":"Hao","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yau Kei","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7150-8868","authenticated-orcid":false,"given":"Shuangquan","family":"Lai","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1765-5244","authenticated-orcid":false,"given":"Yi","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010020\u20100145\u20105"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.2.403\u2010434.2006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010022\u201000682\u20104"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(01)05321\u20101"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.99"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44490"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010019\u20100092\u20101"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00067.2017"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)02724\u20100"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010020\u20100420\u20101"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2024.08.010"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202212300"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c09107"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adt3159"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c03858"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201058061\u20105"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010021\u201000415\u20100"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3997"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.04.029"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.43128"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.66.1.717"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b06794"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202405405"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201020547\u20109"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201803977"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202004393"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2018.04.005"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201022278\u2010x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202418731"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202502147"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307624"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c08518"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2026.112609"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427\u2010023\u20102621\u20107"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40635\u2010019\u20100281\u2010y"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20240415"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c09639"},{"key":"e_1_2_8_41_1","first-page":"9","article-title":"Defect\u2010Based Lewis Pairs on Hydrophobic MnO Mesocrystals for Robust and Efficient Ozone Decomposition","volume":"16","author":"Yang J. L.","year":"2025","journal-title":"Nature Communications"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c18040"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202511173"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201063550\u20108"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202413171"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202409400"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202413171"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202419426"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202106929"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adm9561"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202410381"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201045619\u2010y"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202521580"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040830\u20109"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aeb9792"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201050453\u20103"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310599"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202413276"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202313997"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202207275"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102250"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.812588"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3032"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010020\u20100230\u20103"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c09525"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2020.213601"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7053536"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020607"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891\u20105849(94)90007\u20108"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.123011"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.9441573","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.9441573","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.9441573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:50:30Z","timestamp":1789041030000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.9441573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":69,"alternative-id":["10.1002\/anie.9441573"],"URL":"https:\/\/doi.org\/10.1002\/anie.9441573","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]},"assertion":[{"value":"2026-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9441573"}}