{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:58:21Z","timestamp":1791226701884,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"41","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Candida auris<\/jats:italic>\n                    is an emerging multidrug\u2010resistant fungal pathogen for which neither vaccines nor rapid diagnostics are available. Defined fungal glycan epitopes offer a chemically precise route toward both immunization and detection. Here, we show that a synthetic \u03b2\u2010mannan tetrasaccharide, \u03b2\u2010(1,2)Man\u2010\u03b1\u2010(1,2)Man\u2010\u03b1\u2010(1,2)Man\u2010\u03b1\u2010(1,2)Man, functions as a lead epitope against\n                    <jats:italic>C. auris<\/jats:italic>\n                    . Conjugation of this glycan to the carrier protein CRM\n                    <jats:sub>197<\/jats:sub>\n                    afforded a glycoconjugate that elicited epitope\u2010selective immunoglobulin M (IgM) and immunoglobulin G (IgG) responses and reduced fungal burden in kidneys and spleen in a murine disseminated infection model. Monoclonal IgG1 antibodies raised against the same synthetic glycan displayed structure\u2010dependent recognition of oligomannosides and\n                    <jats:italic>Candida<\/jats:italic>\n                    cells and enabled passive immunization, resulting in reduced fungal burden in the spleen. One antibody enabled the development of a prototype lateral flow assay for rapid detection of multiple\n                    <jats:italic>Candida<\/jats:italic>\n                    species. The defined synthetic \u03b2\u2010mannan epitope connects glycoconjugate immunization with antibody\u2010based recognition and establishes a chemically defined platform for antifungal intervention and detection.\n                  <\/jats:p>","DOI":"10.1002\/anie.9466991","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:34:52Z","timestamp":1786451692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Synthetic \u03b2\u2010Mannan Epitope Enables Immunization and Detection of\n                    <i>Candida auris<\/i>"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0624-542X","authenticated-orcid":false,"given":"Emelie E.","family":"Reuber","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"},{"name":"Department of Biomolecular Systems Max Planck Institute of Colloids and Interfaces  Potsdam Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnab","family":"Pradhan","sequence":"additional","affiliation":[{"name":"MRC Centre for Medical Mycology University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Leaves","sequence":"additional","affiliation":[{"name":"MRC Centre for Medical Mycology University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"},{"name":"Department of Biomolecular Systems Max Planck Institute of Colloids and Interfaces  Potsdam Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emer","family":"Hickey","sequence":"additional","affiliation":[{"name":"MRC Centre for Medical Mycology University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Geiler","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Systems Max Planck Institute of Colloids and Interfaces  Potsdam Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2776-5850","authenticated-orcid":false,"given":"Neil A. 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