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Previous work has focused on the development of peptides that can compete with native autoinducing peptides (AIPs), to antagonize the receptor histidine kinase responsible for activation of quorum sensing and thereby repress the expression of virulence genes. Here we report simple analogues of cysteine that can eliminate the native AIPs extracellularly, before they activate their receptor, and validate that this alternative strategy can also be applied to turn off quorum sensing in different\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    reporter strain assays. Further, we show that two selected compounds can reduce skin infection caused by MRSA in a murine model. This work provides impetus for the development of simple small molecules for the topical treatment of staphylococcal skin infections. We anticipate that further studies, including delivery strategies, will help illuminate this potential.\n                  <\/jats:p>","DOI":"10.1002\/anie.9489770","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:15:12Z","timestamp":1784801712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Repression of Virulence in\n                    <i>Staphylococcus aureus<\/i>\n                    by 2\u2010Aminothiol\u2010Mediated Quorum Quenching"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0935-3278","authenticated-orcid":false,"given":"Bengt H.","family":"Gless","sequence":"first","affiliation":[{"name":"Center For Biopharmaceuticals and Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6041-7412","authenticated-orcid":false,"given":"Riccardo","family":"Milazzo","sequence":"additional","affiliation":[{"name":"Center For Biopharmaceuticals and Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8488-9593","authenticated-orcid":false,"given":"Martin S.","family":"Bojer","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences Faculty of Health and Medical Sciences University of Copenhagen  Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3789-4381","authenticated-orcid":false,"given":"Benjamin S.","family":"Sereika\u2010Bejder","sequence":"additional","affiliation":[{"name":"Center For Biopharmaceuticals and Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8350-5631","authenticated-orcid":false,"given":"Hanne","family":"Ingmer","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences Faculty of Health and Medical Sciences University of Copenhagen  Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2953-8942","authenticated-orcid":false,"given":"Christian A.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Center For Biopharmaceuticals and Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00081\u201009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(09)61999\u20101"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.33"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.26.12055"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5321.2027"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.23"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.21.012704.131001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010019\u20100186\u20105"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2016.01.004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00967\u201025"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah4680"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.11.001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00172\u201020"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010021\u201001256\u20102"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010019\u20100256\u20103"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7973629"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.3c00095"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2009.02.011"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja3112115"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2013.05.008"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.5c00633"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.05.057"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200316876"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01733"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01949"}],"container-title":["Angewandte 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