{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:41:16Z","timestamp":1792262476557,"version":"4.4.0"},"reference-count":69,"publisher":"Wiley","issue":"43","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1305100"],"award-info":[{"award-number":["2022YFA1305100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52373121"],"award-info":[{"award-number":["52373121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52573143"],"award-info":[{"award-number":["52573143"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,10,19]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Peptide coacervates formed via liquid\u2013liquid phase separation (LLPS) have emerged as versatile cell\u2010like compartments for protocell studies and spatially confined catalysis. However, achieving remote, noninvasive modulation of their assembly\u2012disassembly lifecycle remains a key challenge. Here, we report a supramolecular design that enables light\u2010 and pH\u2010gated reversible coacervation of peptides through non\u2010covalent integration of spiropyran photoswitches. The mechanism relies on photoisomerization\u2010induced charge shift in spiropyran, which consequently modulates interpeptide electrostatic interactions to drive coacervate formation. Dissociation occurs reversibly via thermal relaxation upon the cessation of light, a process further regulated by pH, thereby enabling distinct on\u2010demand on\u2010 and off\u2010coacervation regimes. We validate this principle through systematic structural variations of both components, establishing a direct link between molecular design and phase behavior. Exploiting their reversible sequestration capability, we demonstrate that these coacervates serve as efficient light\u2011 and pH\u2010activated microreactors with\n                    <jats:bold>OR<\/jats:bold>\n                    logic gate functions that are capable of accelerating cascade reactions under dilute conditions and as dynamic reusable templates with cascaded\n                    <jats:bold>OR<\/jats:bold>\n                    \u2013\n                    <jats:bold>AND<\/jats:bold>\n                    logic gate functions for recyclable synthesis of nanogels with tunable dimensions. This work establishes a versatile approach for dual\u2010mode regulation of peptide coacervates, opening avenues for the development of photo\u2010 and pH\u2010responsive microreactors and adaptive templates for material synthesis.\n                  <\/jats:p>","DOI":"10.1002\/anie.9579523","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:25:11Z","timestamp":1788542711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Light\u2010 and pH\u2010Gated Reversible Modulation of Peptide Coacervates via Noncovalent Integration of Spiropyran Photoswitches"],"prefix":"10.1002","volume":"65","author":[{"given":"Yifan","family":"Zheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China  Hefei Anhui China"},{"name":"School of Chemistry and Materials Science University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China  Hefei Anhui China"},{"name":"School of Chemistry and Materials Science University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4199-4381","authenticated-orcid":false,"given":"Hanbo","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China  Hefei Anhui China"},{"name":"School of Chemistry and Materials Science University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China  Hefei Anhui China"},{"name":"School of Chemistry and Materials Science University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China  Hefei Anhui China"},{"name":"School of Chemistry and Materials Science University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1152-5985","authenticated-orcid":false,"given":"Yi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2653-8963","authenticated-orcid":false,"given":"Yue","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China  Hefei Anhui China"},{"name":"School of Chemistry and Materials Science University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8948-8537","authenticated-orcid":false,"given":"Kohei","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Science Kwansei Gakuin University  Sanda Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1573-5208","authenticated-orcid":false,"given":"Chuang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China  Hefei Anhui China"},{"name":"School of Chemistry and Materials Science University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf4382"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010025\u201002053\u20105"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c01526"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202422175"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010025\u201001827\u20107"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c03870"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010024\u201001489\u2010x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010025\u201001837\u20105"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010025\u201002434\u20100"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010025\u201001941\u20100"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010024\u201001705\u20108"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010025\u201002202\u20100"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CS01203H"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005223\u2010w"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.3c00592"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201057772\u2010z"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c05101"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010024\u201001766\u20103"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2023.05.009"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00307G"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2025.102578"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c13139"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.4c00738"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010021\u201000788\u2010x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202420399"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c10784"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010025\u201002300\u2010z"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.9334343"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c01377"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.06.016"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202519473"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202421620"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202512266"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6c06781"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c05624"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202519342"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c09557"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202422601"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202117500"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202505316"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201909228"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf9000"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202415550"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202419538"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201064993\u20109"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202500242"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202307045"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202514781"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.5c04456"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202413810"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202405765"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5CC04182A"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC00805J"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC03152F"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc34677j"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202400544"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202200635"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c02201"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202500857"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10118\u2010024\u20103211\u20108"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201046100\u20106"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c15328"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw8653"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202109250"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201021181\u20109"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201041864\u20109"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010025\u201001901\u20100"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201069459\u20100"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.9579523","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.9579523","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.9579523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:43:13Z","timestamp":1792258993000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.9579523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":69,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2026,10,19]]}},"alternative-id":["10.1002\/anie.9579523"],"URL":"https:\/\/doi.org\/10.1002\/anie.9579523","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,4]]},"assertion":[{"value":"2026-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9579523"}}