{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:50:32Z","timestamp":1791229832877,"version":"4.1.0"},"reference-count":83,"publisher":"Wiley","issue":"41","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["I001920N"],"award-info":[{"award-number":["I001920N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G025924N"],"award-info":[{"award-number":["G025924N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1273724N"],"award-info":[{"award-number":["1273724N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["V445124N"],"award-info":[{"award-number":["V445124N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012220","name":"Hercules Foundation","doi-asserted-by":"publisher","award":["AKUL\/09\/0035"],"award-info":[{"award-number":["AKUL\/09\/0035"]}],"id":[{"id":"10.13039\/100012220","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Multi\u2010stimuli\u2010responsive assembly of water\u2010soluble, high\u2010nuclearity metal\u2013organic cages (MOCs) offers attractive opportunities for adaptive supramolecular systems, but balancing structural definition with flexibility remains a central challenge. Here, we report that an adaptive ligand (\n                    <jats:bold>L2<\/jats:bold>\n                    ) enables access to a series of M\n                    <jats:sub>3n<\/jats:sub>\n                    L\n                    <jats:sub>2n<\/jats:sub>\n                    cages within a single coordination framework, including octahedral, tubular, and bowl\u2010shaped Pd\n                    <jats:sub>6<\/jats:sub>\n                    (\n                    <jats:bold>L2<\/jats:bold>\n                    )\n                    <jats:sub>4<\/jats:sub>\n                    cages, as well as a Pd\n                    <jats:sub>12<\/jats:sub>\n                    (\n                    <jats:bold>L2<\/jats:bold>\n                    )\n                    <jats:sub>8<\/jats:sub>\n                    icosahedron. These architectures reversibly interconvert in response to changes in temperature, concentration, solvent environment, and guest binding. In contrast, a rigid analogue (\n                    <jats:bold>L1<\/jats:bold>\n                    ) yields a single Pd\n                    <jats:sub>6<\/jats:sub>\n                    (\n                    <jats:bold>L1<\/jats:bold>\n                    )\n                    <jats:sub>4<\/jats:sub>\n                    octahedral cage. Mechanistic studies, combined with single\u2010crystal X\u2010ray diffraction analysis, reveal that interconversion between cages of different nuclearities proceeds primarily via cage isomerization within intact frameworks rather than through classical stepwise growth, providing a kinetically efficient route to higher\u2010order structural complexity and organization. These results establish the integration of conformational adaptivity with cage isomerization pathways as a general design principle for multi\u2010stimuli\u2010responsive supramolecular systems in water.\n                  <\/jats:p>","DOI":"10.1002\/anie.9635291","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:22:51Z","timestamp":1786551771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Conformational Adaptivity and Isomerization Pathway Enable Multi\u2010Stimuli\u2010Responsive Assembly and Interconversion of Water\u2010Soluble Metal\u2013Organic Cages"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5353-0094","authenticated-orcid":false,"given":"Cui\u2010Lian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Chemistry KU Leuven  Leuven Belgium"},{"name":"Van \u2019t Hoff Institute for Molecular Sciences University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9518-3625","authenticated-orcid":false,"given":"Chongting","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Chemistry KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6278-2720","authenticated-orcid":false,"given":"Rens","family":"Ham","sequence":"additional","affiliation":[{"name":"Van \u2019t Hoff Institute for Molecular Sciences University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9737-687X","authenticated-orcid":false,"given":"Xu","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Chemistry KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9403-2554","authenticated-orcid":false,"given":"Rongwei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Chemistry KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2186-5209","authenticated-orcid":false,"given":"Luc","family":"Van Meervelt","sequence":"additional","affiliation":[{"name":"Department of Chemistry KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5024-508X","authenticated-orcid":false,"given":"Joost N. H.","family":"Reek","sequence":"additional","affiliation":[{"name":"Van \u2019t Hoff Institute for Molecular Sciences University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6188-3957","authenticated-orcid":false,"given":"Tatjana N.","family":"Parac\u2010Vogt","sequence":"additional","affiliation":[{"name":"Department of Chemistry KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44160\u2010023\u201000276\u20109"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20771"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175313"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/19740"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199610841"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202403856"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.4c00934"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010020\u201000246\u20101"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC04272F"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b05157"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2024.08.011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201504930"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2025.217032"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CC05935A"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202102095"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b05872"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2025.102784"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44160\u2010024\u201000606\u20105"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00811"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010020\u20100652\u20102"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200805340"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr5005666"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200077m"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc43191f"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.023.202302940"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00301"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2021.706462"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202001399"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214612"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar068185n"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202416332"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202106721"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC05534G"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar010142d"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b02445"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.12.5394"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00301F"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521\u20103765(19990903)5:9<2455::AID\u2010CHEM2455>3.0.CO;2\u2010H"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja984046s"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.4c04965"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c11536"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2022.01.003"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja107403p"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr500495x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.232"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.10.4848"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00801J"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr500632f"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.202100657"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201509278"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201311251"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c08666"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c02491"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b11099"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202416076"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201800490"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200605084"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.4c03339"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic502780b"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202403711"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c12504"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b12738"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010023\u201001387\u20108"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1246\/cl.200076"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201508307"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201509265"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c06102"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.5709785"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00672"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c20185"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202422143"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202401940"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c14509"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201050972\u2010z"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010020\u20100455\u2010y"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2019.03.014"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201201679"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521\u20103773(20010518)40:10<1879::AID\u2010ANIE1879>3.0.CO;2\u2010I"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/378469a0"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202518649"},{"key":"e_1_2_8_82_1","unstructured":"Deposition numbers 2535806 (for Pd12(L2)8(NO3)24Icosahedron) 2535805 (for bowl\u2011like Pd6(L2)4(PF6)12architecture) and 2535807 (for co\u2010crystal ofG1and Pd12(L2)8Icosahedron) contain the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe Access Structures service."},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010023\u201001415\u20107"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar00033a003"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.9635291","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.9635291","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.9635291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:50:31Z","timestamp":1791226231000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.9635291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":83,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2026,10,5]]}},"alternative-id":["10.1002\/anie.9635291"],"URL":"https:\/\/doi.org\/10.1002\/anie.9635291","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]},"assertion":[{"value":"2026-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9635291"}}