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To address these challenges, we develop an efficient copper\u2010based single\u2010atom nanozyme platform (CuN\n                    <jats:sub>3<\/jats:sub>\n                    Cl\u2010BAY@COD) via a facile axial coordination and defect engineering strategy to boost immunotherapy by driving synergistic disulfidptosis and pyroptosis. This dual\u2010engineering strategy effectively regulates the electronic and geometric structures of Cu sites, resulting in significantly improved multienzyme\u2010mimicking activities. Such enhanced multienzyme\u2010mimicking activities endow CuN\n                    <jats:sub>3<\/jats:sub>\n                    Cl\u2010BAY@COD with the robust capacity to disrupt intracellular redox homeostasis and amplify the disulfide stress mediated by BAY\u2010876, inducing efficient tumor cell pyroptosis and disulfidptosis. The loaded cholesterol oxidase degrades cholesterol to inhibit tumor cell invasion while elevating intracellular hydrogen peroxide levels to exacerbate pyroptosis. In summary, by coupling metabolic reprogramming with dual immunogenic cell death, this engineered nanoplatform overcomes TME resistance barriers, providing a robust strategy for prostate cancer immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/anie.9645080","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:54:48Z","timestamp":1783616088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Axial Coordination and Defect Engineering of Copper\u2010Based Single\u2010Atom Nanozymes: Driving Synergistic Disulfidptosis and Pyroptosis for Efficient Prostate Cancer Immunotherapy"],"prefix":"10.1002","volume":"65","author":[{"given":"Bo","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Urology The First Hospital of Jilin University  Changchun Jilin 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